FTSK_MYCLE
ID FTSK_MYCLE Reviewed; 840 AA.
AC O05560;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 29-AUG-2003, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=DNA translocase FtsK;
GN Name=ftsK; OrderedLocusNames=ML0977; ORFNames=MLCB33.09c;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the Xer recombinase, allowing
CC activation of chromosome unlinking by recombination (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Note=Located at the septum. {ECO:0000250}.
CC -!- DOMAIN: Consists of an N-terminal domain, which is sufficient for the
CC localization to the septal ring and is required for cell division,
CC followed by a linker domain, and a C-terminal domain, which forms the
CC translocation motor involved in chromosome segregation. The C-terminal
CC domain can be further subdivided into alpha, beta and gamma subdomains.
CC The alpha and beta subdomains form the DNA pump, and the gamma
CC subdomain is a regulatory subdomain (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB08120.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAC31358.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; Z94723; CAB08120.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL583920; CAC31358.1; ALT_INIT; Genomic_DNA.
DR PIR; C87031; C87031.
DR RefSeq; WP_010908050.1; NC_002677.1.
DR AlphaFoldDB; O05560; -.
DR SMR; O05560; -.
DR STRING; 272631.ML0977; -.
DR EnsemblBacteria; CAC31358; CAC31358; CAC31358.
DR KEGG; mle:ML0977; -.
DR Leproma; ML0977; -.
DR eggNOG; COG1674; Bacteria.
DR HOGENOM; CLU_001981_2_1_11; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell cycle; Cell division; Cell membrane;
KW Chromosome partition; DNA-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..840
FT /note="DNA translocase FtsK"
FT /id="PRO_0000098270"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..840
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 479..679
FT /note="FtsK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 499..504
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 840 AA; 89716 MW; 48F70EB38315A3A9 CRC64;
MASKTVARSG NRTSSLKATS RGVSQSRRPV PPRPRRNRPA ERRNQSLLLA AGLTCGQAIR
ATWLVAAKGA GGAARSIGRA RDIEPGHRRD GIALALLGLA VVVAASSWFD AARPIGAWVD
AVLRTFIGSA VVVLPLVIAA VAVVLMRTQP NLDTRPRLIL GATLIALSFL GLRHLWSGSP
ETPEVRRGAA GFLGFAIGGP LSDGLTAWIA APLLFIGALF GLLLLTGTTV REVPEVLRGM
FDTGLFQRDY DDQYDAEYRY DDIPGAPPED FSGCYDGSLV GGGDAEQKVR GWPVTDLAEV
SLQDDVPTTP EPAVQAGTAE VHRLTPRSAE EHRTQALDRA IEGSYTLPSM SLLLTGDPPK
KCSAANNHMA SAIGGVLTQF KVDAAVTGCT RGPTVTRYEV ELGPGVKVEK ITALQKNIAY
AVATESVRML APIPGKSAVG IEVPNTDREA VRLADVLTAP STRRDHHSLV IGLGKDIEGN
FISANLAKMP HLLVAGSTGS GKSSFVNSML VSLLTRSTPE EVRMILIDPK MVELTPYEGI
PHLITPIITQ PKKAAAALVW LVEEMEQRYQ DMQASRVRHI DVFNEKVRSG EITAPLGSQR
VYRPYPYILA IVDELADLMM TAPRDVEDAI VRITQKARAA GIHLVLATQR PSVDVVTGLI
KTNVPSRLAF ATSSLTDSRV ILDQAGAEKL IGMGDGLFLP MGASKPVRLQ GAFITDEEIH
AVVTACKDQA EPEYTEGVTT AKTTGERTDV DPDIGDDMDV FLQAVELVVS SQFGSTSMLQ
RKLRVGFAKA GRLMDLMETR SIVGPSEGSK AREVLVKADE LAATLALIRG GASADGSNED
