ID   FTSK_PSEU2              Reviewed;         801 AA.
AC   Q9Z3U1; Q4ZRL1;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=DNA translocase FtsK;
GN   Name=ftsK; OrderedLocusNames=Psyr_3179;
OS   Pseudomonas syringae pv. syringae (strain B728a).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX   NCBI_TaxID=205918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kisncherf T.G., Hirano S.S., Willis D.K.;
RT   "A transposon insertion in the ftsK/spoIIIE gene impairs in planta growth
RT   and lesion forming abilities in Pseudomonas syringae pv. syringae B728a.";
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B728a;
RX   PubMed=16043691; DOI=10.1073/pnas.0504930102;
RA   Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A.,
RA   Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S.,
RA   Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M.,
RA   Kyrpides N.C., Ivanova N., Lindow S.E.;
RT   "Comparison of the complete genome sequences of Pseudomonas syringae pv.
RT   syringae B728a and pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005).
CC   -!- FUNCTION: Essential cell division protein that coordinates cell
CC       division and chromosome segregation. The N-terminus is involved in
CC       assembly of the cell-division machinery. The C-terminus functions as a
CC       DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC       recombination site, which is located within the replication terminus
CC       region. Translocation stops specifically at Xer-dif sites, where FtsK
CC       interacts with the Xer recombinase, allowing activation of chromosome
CC       unlinking by recombination. FtsK orienting polar sequences (KOPS) guide
CC       the direction of DNA translocation. FtsK can remove proteins from DNA
CC       as it translocates, but translocation stops specifically at XerCD-dif
CC       site, thereby preventing removal of XerC and XerD from dif (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Note=Located at the septum.
CC       {ECO:0000250}.
CC   -!- DOMAIN: Consists of an N-terminal domain, which is sufficient for the
CC       localization to the septal ring and is required for cell division,
CC       followed by a linker domain, and a C-terminal domain, which forms the
CC       translocation motor involved in chromosome segregation. The C-terminal
CC       domain can be further subdivided into alpha, beta and gamma subdomains.
CC       The alpha and beta subdomains multimerise to produce a hexameric ring,
CC       contain the nucleotide binding motif and form the DNA pump. The gamma
CC       subdomain is a regulatory subdomain that controls translocation of DNA
CC       by recognition of KOPS motifs and interacts with XerD recombinase (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family. {ECO:0000305}.
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DR   EMBL; AF095845; AAC98298.1; -; Genomic_DNA.
DR   EMBL; CP000075; AAY38211.1; -; Genomic_DNA.
DR   RefSeq; WP_003405080.1; NC_007005.1.
DR   RefSeq; YP_236249.1; NC_007005.1.
DR   AlphaFoldDB; Q9Z3U1; -.
DR   SMR; Q9Z3U1; -.
DR   STRING; 205918.Psyr_3179; -.
DR   EnsemblBacteria; AAY38211; AAY38211; Psyr_3179.
DR   KEGG; psb:Psyr_3179; -.
DR   PATRIC; fig|205918.7.peg.3244; -.
DR   eggNOG; COG1674; Bacteria.
DR   HOGENOM; CLU_001981_9_7_6; -.
DR   OMA; YKAEARD; -.
DR   Proteomes; UP000000426; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR025199; FtsK_4TM.
DR   InterPro; IPR041027; FtsK_alpha.
DR   InterPro; IPR002543; FtsK_dom.
DR   InterPro; IPR018541; Ftsk_gamma.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13491; FtsK_4TM; 1.
DR   Pfam; PF17854; FtsK_alpha; 1.
DR   Pfam; PF09397; FtsK_gamma; 1.
DR   Pfam; PF01580; FtsK_SpoIIIE; 1.
DR   SMART; SM00843; Ftsk_gamma; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50901; FTSK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Cell inner membrane; Cell membrane;
KW   Chromosome partition; DNA-binding; Membrane; Nucleotide-binding;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..801
FT                   /note="DNA translocase FtsK"
FT                   /id="PRO_0000098281"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..801
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          441..653
FT                   /note="FtsK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT   REGION          715..736
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         461..466
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
SQ   SEQUENCE   801 AA;  87657 MW;  84D2645B57C1006D CRC64;
     MKKSTPAPSA VPLWRQQLHY RLKEGALIAF GALCLYLMMA LLTYDQSDPG WSHTSSNAAQ
     VQNAAGRAGA FCADILFMIL GYFAYIFPLL LAIKAWQVFR HRHEPWQWSG WLFSWRLIGL
     VFLILAGAAL AHIHFHFSAG FPGSAGGVLG EVLGDLAKKA LNIQGSTLLF IALFLFGLTV
     FTDLSWFKVM DVTGKITLDL FELFQGAANR WWTARAERKQ MVAQLREVDM RVNDVVAPVA
     PDRREQAKAR ERLVEREASL SKHMTEREKH VPAVIAPAPS KPVEPSKRVM KEKQAPLFVD
     SAVEGTLPPI SILDPAEKKQ LNYSPESLAA VGHLLEIKLK EFGVEVSVDS IHPGPVITRY
     EIQPAAGVKV SRISNLAKDL ARSLAVTSVR VVEVIPGKTT VGIEIPNEDR QIVRFSEVLS
     TPEYDNAKSP VTLALGHDIG GKPVITDLAK MPHLLVAGTT GSGKSVGVNA MILSILFKSG
     PEDAKLIMID PKMLELSIYE GIPHLLCPVV TDMKDAANAL RWSVAEMERR YKLMAKMGVR
     NLSGFNQKVK EAQDAGEPLA DPLYKRESIH DEAPLLSKLP TIVVVVDEFA DMMMIVGKKV
     EELIARIAQK ARAAGIHLIL ATQRPSVDVI TGLIKANIPT RMAFQVSSKI DSRTIIDQGG
     AEQLLGHGDM LYMPPGTSLP IRVHGAFVSD EEVHRVVEAW KLRGSPDYND DILAGVEEPG
     SGFDGGSGEG SEDSESDALY DEAVKFVLES RRASISAVQR KLKIGYNRAA RMIEAMEMAG
     VVTSMNTNGS REVLAPGPVR D