FTSK_STRMU
ID FTSK_STRMU Reviewed; 787 AA.
AC Q8DSX7;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 29-AUG-2003, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=DNA translocase FtsK;
GN Name=ftsK; OrderedLocusNames=SMU_1629c;
OS Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=210007;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700610 / UA159;
RX PubMed=12397186; DOI=10.1073/pnas.172501299;
RA Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the XerS recombinase, allowing
CC activation of chromosome unlinking by recombination (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Note=Located at the septum. {ECO:0000250}.
CC -!- DOMAIN: Consists of an N-terminal domain, which is sufficient for the
CC localization to the septal ring and is required for cell division,
CC followed by a linker domain, and a C-terminal domain, which forms the
CC translocation motor involved in chromosome segregation. The C-terminal
CC domain can be further subdivided into alpha, beta and gamma subdomains.
CC The alpha and beta subdomains form the DNA pump, and the gamma
CC subdomain is a regulatory subdomain (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN59270.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014133; AAN59270.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_721964.1; NC_004350.2.
DR RefSeq; WP_002352345.1; NC_004350.2.
DR AlphaFoldDB; Q8DSX7; -.
DR SMR; Q8DSX7; -.
DR STRING; 210007.SMU_1629c; -.
DR PRIDE; Q8DSX7; -.
DR EnsemblBacteria; AAN59270; AAN59270; SMU_1629c.
DR KEGG; smu:SMU_1629c; -.
DR PATRIC; fig|210007.7.peg.1452; -.
DR eggNOG; COG1674; Bacteria.
DR HOGENOM; CLU_001981_9_6_9; -.
DR OMA; MTKEPEI; -.
DR Proteomes; UP000002512; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 2.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell cycle; Cell division; Cell membrane;
KW Chromosome partition; DNA-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..787
FT /note="DNA translocase FtsK"
FT /id="PRO_0000098305"
FT TRANSMEM 31..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..787
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 450..647
FT /note="FtsK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 471..476
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 787 AA; 87176 MW; BAD7C3C0BCF3D464 CRC64;
MAKTKNKRKG RKTRRPTKAE LEKQRAIKRM VFALFMAFVL FFAIFKLGRV GVTVYNIIRL
MVGSLAYPFI FAALIYLFAT KWLKKHDGLV GGFVITMLGM LLEWQAYLFS LATMKDQSVI
KGTLVIVFSD LSKFRVANFA GGGFLGALLY MPVAFLFSNI GSFLIGGLFL LLGLFLMSPW
DVYDVMNFFK DSYAKWQVKR QENREKRFAQ KEEARLLAQQ AVQEAQESAT FDHGLNAAID
LETGEVLDQA QTIDLDDFDG QVHKEPEIIG YQSDPEGEAL EAEVPAAEQT SQLPKEEDMS
DESLEVDFTP KTTLHYKLPG IDLFAKDKPK NQSKEKRLVR DNIKILEETF TSFGIKANVE
RAEIGPSVTK YEVKPAVGVR VNRISNLADD LALALAAQDV RIEAPIPGKS LVGIEVPNSE
VATVTFRELW EQAKASPDKL LEVPLGKAVN GSVRSFDLAK MPHILVAGST GSGKSVAVNG
IIASILMKAR PDQIKFMMID PKMVELSVYN DIPHLLIPVV TNPRKASKAL QKVVDEMENR
YELFSHFGVR NIAGYNAKVE EFNRHSETKH IPLPLLVVIV DELADLMMVA SKEVEDAIIR
LGQKARAAGI HMILATQRPS VDVISGLIKA NVPSRIAFAV SSGTDSRTIL DENGAEKLLG
RGDMLFKPID ENHPVRLQGS FISDDDVERI VSFIKEQAEA DYDESFDPGE VSEDDNSNGN
GGNSEGDPLF EDAKALVLET QKASASMLQR RLSVGFNRAT RLMEELEEAG VIGPAEGTKP
RKVLQSN
