FTSN_CAUVN
ID FTSN_CAUVN Reviewed; 266 AA.
AC B8GX61;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Cell division protein FtsN;
GN Name=ftsN; OrderedLocusNames=CCNA_02086;
OS Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=565050;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA1000 / CB15N;
RX PubMed=20472802; DOI=10.1128/jb.00255-10;
RA Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA Walunas T.L., Crosson S.;
RT "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL J. Bacteriol. 192:3678-3688(2010).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, AND DOMAIN.
RC STRAIN=NA1000 / CB15N;
RX PubMed=19400794; DOI=10.1111/j.1365-2958.2009.06706.x;
RA Moll A., Thanbichler M.;
RT "FtsN-like proteins are conserved components of the cell division machinery
RT in proteobacteria.";
RL Mol. Microbiol. 72:1037-1053(2009).
RN [3]
RP INTERACTION WITH FTSI; FTSW AND SIDA.
RC STRAIN=NA1000 / CB15N;
RX PubMed=21685367; DOI=10.1101/gad.2038911;
RA Modell J.W., Hopkins A.C., Laub M.T.;
RT "A DNA damage checkpoint in Caulobacter crescentus inhibits cell division
RT through a direct interaction with FtsW.";
RL Genes Dev. 25:1328-1343(2011).
CC -!- FUNCTION: Essential cell division protein.
CC {ECO:0000269|PubMed:19400794}.
CC -!- SUBUNIT: Interacts with FtsI, FtsW and the cell division inhibitor
CC SidA. {ECO:0000269|PubMed:21685367}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:19400794}; Single-pass membrane protein
CC {ECO:0000269|PubMed:19400794}. Note=Recruited to the divisome after
CC cell division initiates and remains associated with the new poles after
CC cytokinesis is finished. Localization is dependent on FtsZ.
CC -!- DOMAIN: The SPOR domain is dispensable for cell division, but it
CC consolidates the position of FtsN at the cell division site and the
CC cell pole. {ECO:0000269|PubMed:19400794}.
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DR EMBL; CP001340; ACL95551.1; -; Genomic_DNA.
DR RefSeq; WP_010919873.1; NC_011916.1.
DR RefSeq; YP_002517459.1; NC_011916.1.
DR AlphaFoldDB; B8GX61; -.
DR SMR; B8GX61; -.
DR DIP; DIP-61065N; -.
DR IntAct; B8GX61; 3.
DR PRIDE; B8GX61; -.
DR EnsemblBacteria; ACL95551; ACL95551; CCNA_02086.
DR GeneID; 7330392; -.
DR KEGG; ccs:CCNA_02086; -.
DR PATRIC; fig|565050.3.peg.2044; -.
DR HOGENOM; CLU_1048341_0_0_5; -.
DR OMA; PRERGAY; -.
DR OrthoDB; 1805464at2; -.
DR Proteomes; UP000001364; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042834; F:peptidoglycan binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.1070; -; 1.
DR InterPro; IPR007730; SPOR-like_dom.
DR InterPro; IPR036680; SPOR-like_sf.
DR Pfam; PF05036; SPOR; 1.
DR SUPFAM; SSF110997; SSF110997; 1.
DR PROSITE; PS51724; SPOR; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..266
FT /note="Cell division protein FtsN"
FT /id="PRO_0000420270"
FT TOPO_DOM 1..32
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..266
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 184..266
FT /note="SPOR"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 266 AA; 26870 MW; 008DD02DCDA515D5 CRC64;
MSDPHRGAYT PPTDAPLSFD ARQPVRGARP LPMTLIISAV VLVTLVVAVV MIYRDGVRGP
NDAPQAVGTE VAQMKTPPAE SSQPKDPASG LQIYHNEEPQ PSATFAAPPE TPLARPVAPT
ATTPVETASL PAAKPAAPAP TIESLATAAA AQKPAPKPVQ VAQAAPKPVA AAPATTATAP
KPAAVSTGPA SVQIGALSSP ALADKAWAEA VRLAPGLAAG KGKKVETVDK NGTTLYRTSV
TGFATREAAK AFCEAIAASG KSCFVK
