FTSQ_MYCTU
ID FTSQ_MYCTU Reviewed; 314 AA.
AC P9WNA1; L0TBG9; O06226; P64168;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 45.
DE RecName: Full=Cell division protein FtsQ {ECO:0000255|HAMAP-Rule:MF_00911};
GN Name=ftsQ {ECO:0000255|HAMAP-Rule:MF_00911}; OrderedLocusNames=Rv2151c;
GN ORFNames=MTCY270.17;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP RETRACTED PAPER.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=20066037; DOI=10.1371/journal.pone.0008590;
RA Sureka K., Hossain T., Mukherjee P., Chatterjee P., Datta P., Kundu M.,
RA Basu J.;
RT "Novel role of phosphorylation-dependent interaction between FtsZ and FipA
RT in mycobacterial cell division.";
RL PLoS ONE 5:E8590-E8590(2010).
RN [3]
RP RETRACTION NOTICE OF PUBMED:20066037.
RX PubMed=35202441; DOI=10.1371/journal.pone.0264672;
RG PLOS ONE Editors;
RL PLoS ONE 17:e0264672-e0264672(2022).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Essential cell division protein. {ECO:0000255|HAMAP-
CC Rule:MF_00911}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00911};
CC Single-pass type II membrane protein {ECO:0000255|HAMAP-Rule:MF_00911}.
CC Note=Localizes to the division septum. {ECO:0000255|HAMAP-
CC Rule:MF_00911}.
CC -!- SIMILARITY: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00911}.
CC -!- CAUTION: The article by Sureka et al was retracted by the editors after
CC publication. Concerns were raised regarding the results presented in
CC multiple figure panels. The raw data or replacement panels that were
CC available did not satisfactorily address all the issues, thus
CC questioning the integrity of the data. {ECO:0000305|PubMed:35202441}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL123456; CCP44927.1; -; Genomic_DNA.
DR PIR; C70579; C70579.
DR RefSeq; NP_216667.1; NC_000962.3.
DR RefSeq; WP_003411157.1; NZ_NVQJ01000044.1.
DR AlphaFoldDB; P9WNA1; -.
DR SMR; P9WNA1; -.
DR IntAct; P9WNA1; 2.
DR STRING; 83332.Rv2151c; -.
DR iPTMnet; P9WNA1; -.
DR PaxDb; P9WNA1; -.
DR DNASU; 888367; -.
DR GeneID; 888367; -.
DR KEGG; mtu:Rv2151c; -.
DR TubercuList; Rv2151c; -.
DR eggNOG; COG1589; Bacteria.
DR OMA; SWPHGIG; -.
DR PhylomeDB; P9WNA1; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0032153; C:cell division site; IEA:UniProtKB-UniRule.
DR GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR GO; GO:0005887; C:integral component of plasma membrane; HDA:MTBBASE.
DR GO; GO:0090529; P:cell septum assembly; IEA:InterPro.
DR GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00911; FtsQ_subfam; 1.
DR InterPro; IPR005548; Cell_div_FtsQ/DivIB_C.
DR InterPro; IPR026579; FtsQ.
DR InterPro; IPR034746; POTRA.
DR InterPro; IPR013685; POTRA_FtsQ_type.
DR Pfam; PF03799; FtsQ; 1.
DR Pfam; PF08478; POTRA_1; 1.
DR PROSITE; PS51779; POTRA; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cell cycle; Cell division; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:21969609"
FT CHAIN 2..314
FT /note="Cell division protein FtsQ"
FT /id="PRO_0000160582"
FT TOPO_DOM 2..99
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00911"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00911"
FT TOPO_DOM 121..314
FT /note="Extracellular"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00911"
FT DOMAIN 124..192
FT /note="POTRA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylthreonine"
FT /evidence="ECO:0007744|PubMed:21969609"
SQ SEQUENCE 314 AA; 33934 MW; FD8C00B41A329D60 CRC64;
MTEHNEDPQI ERVADDAADE EAVTEPLATE SKDEPAEHPE FEGPRRRARR ERAERRAAQA
RATAIEQARR AAKRRARGQI VSEQNPAKPA ARGVVRGLKA LLATVVLAVV GIGLGLALYF
TPAMSAREIV IIGIGAVSRE EVLDAARVRP ATPLLQIDTQ QVADRVATIR RVASARVQRQ
YPSALRITIV ERVPVVVKDF SDGPHLFDRD GVDFATDPPP PALPYFDVDN PGPSDPTTKA
ALQVLTALHP EVASQVGRIA APSVASITLT LADGRVVIWG TTDRCEEKAE KLAALLTQPG
RTYDVSSPDL PTVK
