FTSX_BACAN
ID FTSX_BACAN Reviewed; 297 AA.
AC Q81X30; E9QZ83; E9QZ84; Q6HQW6; Q6KK85;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Cell division protein FtsX {ECO:0000250|UniProtKB:O34876, ECO:0000312|EMBL:AAP29072.1};
GN Name=ftsX {ECO:0000312|EMBL:AAP29072.1};
GN OrderedLocusNames=BA_5415, BAS5033, GBAA_5415;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1] {ECO:0000312|EMBL:AAP29072.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2] {ECO:0000312|EMBL:AAT34552.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [3] {ECO:0000312|EMBL:AAT57322.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP DISRUPTION PHENOTYPE, AND PHARMACEUTICAL.
RC STRAIN=Sterne {ECO:0000269|PubMed:21949405};
RX PubMed=21949405; DOI=10.1073/pnas.1108495108;
RA Crawford M.A., Lowe D.E., Fisher D.J., Stibitz S., Plaut R.D., Beaber J.W.,
RA Zemansky J., Mehrad B., Glomski I.J., Strieter R.M., Hughes M.A.;
RT "Identification of the bacterial protein FtsX as a unique target of
RT chemokine-mediated antimicrobial activity against Bacillus anthracis.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:17159-17164(2011).
CC -!- FUNCTION: Part of the ABC transporter FtsEX involved in asymmetric
CC cellular division facilitating the initiation of sporulation.
CC {ECO:0000250|UniProtKB:O34876}.
CC -!- SUBUNIT: Interacts with FtsE. {ECO:0000250|UniProtKB:O34876}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O34876};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:O34876}.
CC -!- DISRUPTION PHENOTYPE: Vegetative bacilli mutant cells exhibit a
CC distinct morphology in which individual bacilli appear kinked with
CC frequent curves and sharp angles among chains of bacilli. Grows more
CC slowly than wild-type bacteria. Affords resistance of vegetative
CC B.anthracis bacilli to human chemokine CXCL10 regardless of their
CC growth phase and to murine Cxcl9-mediated bactericidal activity. CXCL10
CC treated spores fail to germinate and resume vegetative growth
CC indicating that FtsX is not required for the ability of CXCL10 to
CC target the spore form of B.anthracis. In the absence of FtsX, CXCL10 is
CC unable to localize to its presumed site of action at the bacterial cell
CC membrane. No statistically significant differences are observed between
CC wild-type and deletion mutant bacilli susceptibility to cationic
CC antimicrobial peptide protamine. {ECO:0000269|PubMed:21949405}.
CC -!- PHARMACEUTICAL: Potential therapeutic target of chemokine-mediated
CC antimicrobial activity against B.anthracis to treat infection.
CC {ECO:0000269|PubMed:21949405}.
CC -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family. FtsX
CC subfamily. {ECO:0000255}.
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DR EMBL; AE016879; AAP29072.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT34552.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT57322.1; -; Genomic_DNA.
DR RefSeq; NP_847586.1; NC_003997.3.
DR RefSeq; WP_000645021.1; NZ_WXXJ01000012.1.
DR RefSeq; YP_031272.1; NC_005945.1.
DR AlphaFoldDB; Q81X30; -.
DR SMR; Q81X30; -.
DR STRING; 260799.BAS5033; -.
DR DNASU; 1085005; -.
DR EnsemblBacteria; AAP29072; AAP29072; BA_5415.
DR EnsemblBacteria; AAT34552; AAT34552; GBAA_5415.
DR GeneID; 45025017; -.
DR KEGG; ban:BA_5415; -.
DR KEGG; bar:GBAA_5415; -.
DR KEGG; bat:BAS5033; -.
DR PATRIC; fig|198094.11.peg.5373; -.
DR eggNOG; COG2177; Bacteria.
DR HOGENOM; CLU_073546_2_2_9; -.
DR OMA; ETGIMRL; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IMP:UniProtKB.
DR GO; GO:0045881; P:positive regulation of sporulation resulting in formation of a cellular spore; ISS:UniProtKB.
DR InterPro; IPR003838; ABC3_permease_dom.
DR InterPro; IPR004513; ABC_transpt_FtsX.
DR InterPro; IPR040690; FtsX_ECD.
DR PANTHER; PTHR47755; PTHR47755; 1.
DR Pfam; PF02687; FtsX; 1.
DR Pfam; PF18075; FtsX_ECD; 1.
DR PIRSF; PIRSF003097; FtsX; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cell membrane; Membrane; Pharmaceutical;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..297
FT /note="Cell division protein FtsX"
FT /id="PRO_0000421660"
FT TOPO_DOM 1..24
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255, ECO:0000303|PubMed:21949405"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..171
FT /note="Extracellular"
FT /evidence="ECO:0000255, ECO:0000303|PubMed:21949405"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255, ECO:0000303|PubMed:21949405"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..270
FT /note="Extracellular"
FT /evidence="ECO:0000255, ECO:0000303|PubMed:21949405"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..297
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255, ECO:0000303|PubMed:21949405"
SQ SEQUENCE 297 AA; 33213 MW; E2B302E515F1340B CRC64;
MKAKTLSRHL REGVKNLSRN GWMTFASVSA VTVTLLLVGV FLTAIMNMNH FATKVEQDVE
IRVHIDPAAK EADQKKLEDD MSKIAKVESI KYSSKEEELK RLIKSLGDSG KTFELFEQDN
PLKNVFVVKA KEPTDTATIA KKIEKMQFVS NVQYGKGQVE RLFDTVKTGR NIGIVLIAGL
LFTAMFLISN TIKITIYARS TEIEIMKLVG ATNWFIRWPF LLEGLFLGVL GSIIPIGLIL
VTYNSLQGMF NEKLGGTIFE LLPYSPFVFQ LAGLLVLIGA LIGMWGSVMS IRRFLKV
