ID   FTSX_FLAJ1              Reviewed;         291 AA.
AC   A5FMG4; Q9RB39;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Cell division protein FtsX {ECO:0000250|UniProtKB:P0AC30, ECO:0000312|EMBL:ABQ03602.1};
GN   Name=ftsX {ECO:0000312|EMBL:ABQ03602.1}; OrderedLocusNames=Fjoh_0567;
OS   Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC
OS   14942 / NCIMB 11054 / UW101) (Cytophaga johnsonae).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=376686;
RN   [1] {ECO:0000312|EMBL:AAD50460.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101
RC   {ECO:0000312|EMBL:AAD50460.1};
RX   PubMed=10692373; DOI=10.1128/jb.182.6.1671-1679.2000;
RA   Kempf M.J., McBride M.J.;
RT   "Transposon insertions in the Flavobacterium johnsoniae ftsX gene disrupt
RT   gliding motility and cell division.";
RL   J. Bacteriol. 182:1671-1679(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101;
RX   PubMed=19717629; DOI=10.1128/aem.01495-09;
RA   McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G.,
RA   Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R.,
RA   Cheng Y.Q., Stein J.L.;
RT   "Novel features of the polysaccharide-digesting gliding bacterium
RT   Flavobacterium johnsoniae as revealed by genome sequence analysis.";
RL   Appl. Environ. Microbiol. 75:6864-6875(2009).
CC   -!- FUNCTION: Required for cell division and gliding motility.
CC       {ECO:0000269|PubMed:10692373}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P0AC30}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P0AC30}.
CC   -!- DISRUPTION PHENOTYPE: Filamentous cell morphology and multiple septa.
CC       Filaments cross walls but cells fail to separate. Gliding motility
CC       defects. Resistant to infection by a number of F.johnsoniae
CC       bacteriophages. {ECO:0000269|PubMed:10692373}.
CC   -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family. FtsX
CC       subfamily. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF169967; AAD50460.1; -; Genomic_DNA.
DR   EMBL; CP000685; ABQ03602.1; -; Genomic_DNA.
DR   RefSeq; WP_012022658.1; NZ_MUGZ01000026.1.
DR   AlphaFoldDB; A5FMG4; -.
DR   SMR; A5FMG4; -.
DR   STRING; 376686.Fjoh_0567; -.
DR   EnsemblBacteria; ABQ03602; ABQ03602; Fjoh_0567.
DR   KEGG; fjo:Fjoh_0567; -.
DR   eggNOG; COG2177; Bacteria.
DR   HOGENOM; CLU_073546_3_0_10; -.
DR   OMA; ETGIMRL; -.
DR   OrthoDB; 1653234at2; -.
DR   Proteomes; UP000006694; Chromosome.
DR   GO; GO:0009276; C:Gram-negative-bacterium-type cell wall; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IMP:UniProtKB.
DR   GO; GO:0071976; P:cell gliding; IMP:UniProtKB.
DR   GO; GO:0009615; P:response to virus; IMP:UniProtKB.
DR   InterPro; IPR004513; ABC_transpt_FtsX.
DR   InterPro; IPR040690; FtsX_ECD.
DR   PANTHER; PTHR47755; PTHR47755; 1.
DR   Pfam; PF18075; FtsX_ECD; 1.
DR   PIRSF; PIRSF003097; FtsX; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..291
FT                   /note="Cell division protein FtsX"
FT                   /id="PRO_0000421661"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P0AC30, ECO:0000255"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        40..162
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..220
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P0AC30, ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        242..253
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        275..291
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P0AC30, ECO:0000255"
SQ   SEQUENCE   291 AA;  32935 MW;  918F286DFC8E9512 CRC64;
     MSSNFDKFQK RRLISSYFSV VLSVFLVLFL LGVLGLFIIN SKKLADDFKE KIAMTVFFKN
     EANDSIIKAF NSELKRAPFA LSYVYVTKEK AAKEHTDIIG EDFLTFLGEN PLLNSYDIHL
     KADYVERDSI LKIESALRKN TMIEDIVYDK QLVNLVNDNI KKVSMWILII SGFLTVIAVL
     LINSSLRLSI HSNRFIIKTM QMVGATKSFI RKPFVMRSVK LGMLGALLAI IALIGLLFYV
     ETNFPGLGIL EDKALIGLVL LAVFGLGVLI TWVSTHFATQ RFLNLRTDDL Y