ID   FTSX_MYCBO              Reviewed;         297 AA.
AC   Q7TX91; A0A1R3Y356; X2BMM1;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Cell division protein FtsX;
GN   Name=ftsX; OrderedLocusNames=BQ2027_MB3128C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Part of the ABC transporter FtsEX involved in cellular
CC       division. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a membrane-associated complex with FtsE. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family. FtsX
CC       subfamily. {ECO:0000305}.
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DR   EMBL; LT708304; SIU01754.1; -; Genomic_DNA.
DR   RefSeq; NP_856773.1; NC_002945.3.
DR   RefSeq; WP_010950825.1; NC_002945.4.
DR   AlphaFoldDB; Q7TX91; -.
DR   SMR; Q7TX91; -.
DR   EnsemblBacteria; SIU01754; SIU01754; BQ2027_MB3128C.
DR   PATRIC; fig|233413.5.peg.3438; -.
DR   OMA; ETGIMRL; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; ISS:UniProtKB.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR004513; ABC_transpt_FtsX.
DR   InterPro; IPR040690; FtsX_ECD.
DR   PANTHER; PTHR47755; PTHR47755; 1.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF18075; FtsX_ECD; 1.
DR   PIRSF; PIRSF003097; FtsX; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..297
FT                   /note="Cell division protein FtsX"
FT                   /id="PRO_0000166795"
FT   TOPO_DOM        1..21
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..171
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        193..219
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        241..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..297
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   297 AA;  32792 MW;  7615304E01BBE057 CRC64;
     MRFGFLLNEV LTGFRRNVTM TIAMILTTAI SVGLFGGGML VVRLADSSRA IYLDRVESQV
     FLTEDVSAND SSCDTTACKA LREKIETRSD VKAVRFLNRQ QAYDDAIRKF PQFKDVAGKD
     SFPASFIVKL ENPEQHKDFD TAMKGQPGVL DVLNQKELID RLFAVLDGLS SAAFAVALVQ
     AIGAILLIAN MVQVAAYTRR TEIGIMRLVG ASRWYTQLPF LVEAMLAATM GVGIAVAGLM
     VVRALFLENA LNQFYQANLI AKVDYADILF ITPWLLLLGV AMSGLTAYLT LRLYVRR