ID   FTSX_MYCLE              Reviewed;         297 AA.
AC   O32882;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Cell division protein FtsX;
GN   Name=ftsX; OrderedLocusNames=ML0670; ORFNames=MLCB1779.20c;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Part of the ABC transporter FtsEX involved in cellular
CC       division. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a membrane-associated complex with FtsE. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family. FtsX
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB11001.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; Z98271; CAB11001.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL583919; CAC30179.1; -; Genomic_DNA.
DR   PIR; G86992; G86992.
DR   PIR; T45310; T45310.
DR   RefSeq; NP_301543.1; NC_002677.1.
DR   RefSeq; WP_010907867.1; NC_002677.1.
DR   AlphaFoldDB; O32882; -.
DR   SMR; O32882; -.
DR   STRING; 272631.ML0670; -.
DR   EnsemblBacteria; CAC30179; CAC30179; CAC30179.
DR   KEGG; mle:ML0670; -.
DR   PATRIC; fig|272631.5.peg.1194; -.
DR   Leproma; ML0670; -.
DR   eggNOG; COG2177; Bacteria.
DR   HOGENOM; CLU_073546_1_0_11; -.
DR   OMA; ETGIMRL; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; ISS:UniProtKB.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR004513; ABC_transpt_FtsX.
DR   InterPro; IPR040690; FtsX_ECD.
DR   PANTHER; PTHR47755; PTHR47755; 1.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF18075; FtsX_ECD; 1.
DR   PIRSF; PIRSF003097; FtsX; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..297
FT                   /note="Cell division protein FtsX"
FT                   /id="PRO_0000166796"
FT   TOPO_DOM        1..21
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..171
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        193..219
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        241..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..297
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   297 AA;  32735 MW;  4366E5BA987D58D3 CRC64;
     MRFGFLLNEV VTGLRRNVTM TIAMILTTAI SIGLFGGGLL VVRLADNSRS IYLDRVETQV
     FLTDDISAND LTCNTNLCKA LRGKIEARDD VKSLRFLNRQ DAYDDAIRKF PQYRDVAGKD
     SFPASFIIKL ANPVQHKEFD AATQGQPGVL SVLNQKELID RLFAVLDGLS DVAFVIALVQ
     AIGAILLIAN MVQVAAYTRR TEIGIMRLVG ASRWYTQLPF LLEAMVAATV GAVIAIVGLL
     VARAMFLNNA LNQFYQANLI ARVDYADVLY VSPWLLLLGV ALAALTGYAT LRIYVRR