ID   FTSX_MYCTA              Reviewed;         297 AA.
AC   A5U7B6;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Cell division protein FtsX {ECO:0000312|EMBL:ABQ74916.1};
GN   Name=ftsX {ECO:0000312|EMBL:ABQ74916.1}; OrderedLocusNames=MRA_3133;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1] {ECO:0000312|EMBL:ABQ74916.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
RN   [2] {ECO:0000305}
RP   INDUCTION, AND BIOTECHNOLOGY.
RC   STRAIN=ATCC 25177 / H37Ra {ECO:0000269|PubMed:8921846};
RX   PubMed=8921846; DOI=10.1016/0378-1119(96)00271-5;
RA   Tyagi J.S., Das T.K., Kinger A.K.;
RT   "An M. tuberculosis DNA fragment contains genes encoding cell division
RT   proteins ftsX and ftsE, a basic protein and homologues of PemK and small
RT   protein B.";
RL   Gene 177:59-67(1996).
RN   [3] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH FTSE, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC 25177 / H37Ra {ECO:0000269|PubMed:16416128};
RX   PubMed=16416128; DOI=10.1007/s00203-005-0079-z;
RA   Mir M.A., Rajeswari H.S., Veeraraghavan U., Ajitkumar P.;
RT   "Molecular characterisation of ABC transporter type FtsE and FtsX proteins
RT   of Mycobacterium tuberculosis.";
RL   Arch. Microbiol. 185:147-158(2006).
CC   -!- FUNCTION: Part of the ABC transporter FtsEX involved in cellular
CC       division. {ECO:0000250|UniProtKB:P0AC30, ECO:0000269|PubMed:16416128}.
CC   -!- SUBUNIT: Forms a membrane-associated complex with FtsE.
CC       {ECO:0000269|PubMed:16416128}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16416128};
CC       Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:16416128}.
CC   -!- INDUCTION: Transcription is modulated as a function of mycobacterial
CC       growth and division status, maximum expression being observed in log
CC       phase cells. {ECO:0000269|PubMed:8921846}.
CC   -!- BIOTECHNOLOGY: May provide a basis for developing a marker to
CC       distinguish actively replicating M.tuberculosis cells from quiescent
CC       mycobacteria. {ECO:0000269|PubMed:8921846}.
CC   -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family. FtsX
CC       subfamily. {ECO:0000255}.
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DR   EMBL; CP000611; ABQ74916.1; -; Genomic_DNA.
DR   RefSeq; WP_003416117.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U7B6; -.
DR   SMR; A5U7B6; -.
DR   STRING; 419947.MRA_3133; -.
DR   EnsemblBacteria; ABQ74916; ABQ74916; MRA_3133.
DR   KEGG; mra:MRA_3133; -.
DR   eggNOG; COG2177; Bacteria.
DR   HOGENOM; CLU_073546_1_0_11; -.
DR   OMA; ETGIMRL; -.
DR   OrthoDB; 1653234at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR004513; ABC_transpt_FtsX.
DR   InterPro; IPR040690; FtsX_ECD.
DR   PANTHER; PTHR47755; PTHR47755; 1.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF18075; FtsX_ECD; 1.
DR   PIRSF; PIRSF003097; FtsX; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..297
FT                   /note="Cell division protein FtsX"
FT                   /id="PRO_0000421662"
FT   TOPO_DOM        1..21
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..171
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        193..219
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        241..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..297
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   297 AA;  32819 MW;  67E5304E104BECA7 CRC64;
     MRFGFLLNEV LTGFRRNVTM TIAMILTTAI SVGLFGGGML VVRLADSSRA IYLDRVESQV
     FLTEDVSAND SSCDTTACKA LREKIETRSD VKAVRFLNRQ QAYDDAIRKF PQFKDVAGKD
     SFPASFIVKL ENPEQHKDFD TAMKGQPGVL DVLNQKELID RLFAVLDGLS NAAFAVALVQ
     AIGAILLIAN MVQVAAYTRR TEIGIMRLVG ASRWYTQLPF LVEAMLAATM GVGIAVAGLM
     VVRALFLENA LNQFYQANLI AKVDYADILF ITPWLLLLGV AMSGLTAYLT LRLYVRR