FTSX_MYCTU
ID FTSX_MYCTU Reviewed; 297 AA.
AC P9WG19; L0TBK0; O08113; P96293;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 36.
DE RecName: Full=Cell division protein FtsX;
GN Name=ftsX; OrderedLocusNames=Rv3101c; ORFNames=MTCY164.12c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=8921846; DOI=10.1016/0378-1119(96)00271-5;
RA Tyagi J.S., Das T.K., Kinger A.K.;
RT "An M. tuberculosis DNA fragment contains genes encoding cell division
RT proteins ftsX and ftsE, a basic protein and homologues of PemK and small
RT protein B.";
RL Gene 177:59-67(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Part of the ABC transporter FtsEX involved in cellular
CC division. {ECO:0000250}.
CC -!- SUBUNIT: Forms a membrane-associated complex with FtsE. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family. FtsX
CC subfamily. {ECO:0000305}.
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DR EMBL; X70031; CAA49620.1; -; Genomic_DNA.
DR EMBL; AL123456; CCP45911.1; -; Genomic_DNA.
DR PIR; D70919; D70919.
DR RefSeq; NP_217617.1; NC_000962.3.
DR RefSeq; WP_003416117.1; NZ_NVQJ01000011.1.
DR PDB; 4N8N; X-ray; 1.87 A; A/B/C/D=45-157.
DR PDB; 4N8O; X-ray; 2.30 A; A/B=45-157.
DR PDBsum; 4N8N; -.
DR PDBsum; 4N8O; -.
DR AlphaFoldDB; P9WG19; -.
DR SMR; P9WG19; -.
DR STRING; 83332.Rv3101c; -.
DR PaxDb; P9WG19; -.
DR DNASU; 888673; -.
DR GeneID; 888673; -.
DR KEGG; mtu:Rv3101c; -.
DR TubercuList; Rv3101c; -.
DR eggNOG; COG2177; Bacteria.
DR OMA; ETGIMRL; -.
DR PhylomeDB; P9WG19; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; HDA:MTBBASE.
DR GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; ISS:UniProtKB.
DR InterPro; IPR003838; ABC3_permease_dom.
DR InterPro; IPR004513; ABC_transpt_FtsX.
DR InterPro; IPR040690; FtsX_ECD.
DR PANTHER; PTHR47755; PTHR47755; 1.
DR Pfam; PF02687; FtsX; 1.
DR Pfam; PF18075; FtsX_ECD; 1.
DR PIRSF; PIRSF003097; FtsX; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Cell division; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..297
FT /note="Cell division protein FtsX"
FT /id="PRO_0000166797"
FT TOPO_DOM 1..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..171
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..297
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT STRAND 58..62
FT /evidence="ECO:0007829|PDB:4N8N"
FT HELIX 64..67
FT /evidence="ECO:0007829|PDB:4N8N"
FT STRAND 71..73
FT /evidence="ECO:0007829|PDB:4N8N"
FT HELIX 76..86
FT /evidence="ECO:0007829|PDB:4N8N"
FT STRAND 91..97
FT /evidence="ECO:0007829|PDB:4N8N"
FT HELIX 99..109
FT /evidence="ECO:0007829|PDB:4N8N"
FT HELIX 111..115
FT /evidence="ECO:0007829|PDB:4N8N"
FT STRAND 125..132
FT /evidence="ECO:0007829|PDB:4N8N"
FT HELIX 133..135
FT /evidence="ECO:0007829|PDB:4N8N"
FT HELIX 136..144
FT /evidence="ECO:0007829|PDB:4N8N"
FT STRAND 149..153
FT /evidence="ECO:0007829|PDB:4N8N"
SQ SEQUENCE 297 AA; 32819 MW; 67E5304E104BECA7 CRC64;
MRFGFLLNEV LTGFRRNVTM TIAMILTTAI SVGLFGGGML VVRLADSSRA IYLDRVESQV
FLTEDVSAND SSCDTTACKA LREKIETRSD VKAVRFLNRQ QAYDDAIRKF PQFKDVAGKD
SFPASFIVKL ENPEQHKDFD TAMKGQPGVL DVLNQKELID RLFAVLDGLS NAAFAVALVQ
AIGAILLIAN MVQVAAYTRR TEIGIMRLVG ASRWYTQLPF LVEAMLAATM GVGIAVAGLM
VVRALFLENA LNQFYQANLI AKVDYADILF ITPWLLLLGV AMSGLTAYLT LRLYVRR
