ID   FTSX_NEIGO              Reviewed;         305 AA.
AC   P95357;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Cell division protein FtsX;
GN   Name=ftsX;
OS   Neisseria gonorrhoeae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=CH811;
RX   PubMed=10819322; DOI=10.1093/dnares/7.2.75;
RA   Bernatchez S., Francis F.M., Salimnia H., Beveridge T.J., Li H.,
RA   Dillon J.-A.R.;
RT   "Genomic, transcriptional and phenotypic analysis of ftsE and ftsX of
RT   Neisseria gonorrhoeae.";
RL   DNA Res. 7:75-81(2000).
CC   -!- FUNCTION: Part of the ABC transporter FtsEX involved in cellular
CC       division. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a membrane-associated complex with FtsE. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Viable. Exhibits morphological abnormalities
CC       indicative of defective division sites. While division in wild-type
CC       cells occurs along sequential, alternating division planes, the mutant
CC       is characterized by the presence of multiple and atypically arranged
CC       division sites which frequently divide the cytoplasm into small
CC       cellular compartments. In wild-type cells, the replication and
CC       segregation of DNA precedes the ingrowth of a septum resulting in two
CC       equally sized daughter cells, the process of which is not seen in
CC       mutant cells. Presence of large vacuole-like spaces in the cytoplasm
CC       which appear to be filled with condensed DNA (but few ribosomes) that
CC       has not been able to correctly segregate during cell division.
CC       {ECO:0000269|PubMed:10819322}.
CC   -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family. FtsX
CC       subfamily. {ECO:0000305}.
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DR   EMBL; U76418; AAB36525.1; -; Genomic_DNA.
DR   RefSeq; WP_003688074.1; NZ_WHPL01000002.1.
DR   AlphaFoldDB; P95357; -.
DR   SMR; P95357; -.
DR   GeneID; 66754195; -.
DR   GO; GO:0009276; C:Gram-negative-bacterium-type cell wall; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IMP:UniProtKB.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IMP:UniProtKB.
DR   InterPro; IPR004513; ABC_transpt_FtsX.
DR   InterPro; IPR040690; FtsX_ECD.
DR   PANTHER; PTHR47755; PTHR47755; 1.
DR   Pfam; PF18075; FtsX_ECD; 1.
DR   PIRSF; PIRSF003097; FtsX; 1.
DR   TIGRFAMs; TIGR00439; ftsX; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..305
FT                   /note="Cell division protein FtsX"
FT                   /id="PRO_0000166798"
FT   TOPO_DOM        1..28
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..175
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        197..229
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..268
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..305
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   305 AA;  34213 MW;  9C780DF78A410AEF CRC64;
     MSIIHYFSLH VESARSALKQ LLRQPFGTLL TLIMLAVAMT LPLFMYLGIQ SGQSVLGKLN
     ESPQITVYME TAAAQSDSDT VRSLLTRDKR LDNIRFIGKE DGLAELQSNL DQNLISMLDG
     NPLPDVFIVT PDPATTPAQM QAIYRDITKL PMVESASMDT EWVQTLYQIN EFIRKILWFL
     SLTLGMAFVL VAHNTIRLQI LSRKEEIEIT KLLGAPASFI RRPFLYQAMW QSIFSAAVSL
     GLCGWLLSAV RPLVDAIFKP YGLNIGWRFF YVGELGLVFG FVIALGVFGA WLATTQHLLC
     FKAKK