FTSX_SHIFL
ID FTSX_SHIFL Reviewed; 352 AA.
AC P0AC32; P10122;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Cell division protein FtsX;
GN Name=ftsX; OrderedLocusNames=SF3480, S4283;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Part of the ABC transporter FtsEX involved in cellular
CC division. Important for assembly or stability of the septal ring.
CC Encoded in an operon consisting of genes ftsY, ftsE and ftsX (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms a membrane-associated complex with FtsE. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family. FtsX
CC subfamily. {ECO:0000305}.
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DR EMBL; AE005674; AAN44939.2; -; Genomic_DNA.
DR EMBL; AE014073; AAP19243.1; -; Genomic_DNA.
DR RefSeq; NP_709232.2; NC_004337.2.
DR RefSeq; WP_001042003.1; NZ_WPGW01000010.1.
DR AlphaFoldDB; P0AC32; -.
DR SMR; P0AC32; -.
DR STRING; 198214.SF3480; -.
DR EnsemblBacteria; AAN44939; AAN44939; SF3480.
DR EnsemblBacteria; AAP19243; AAP19243; S4283.
DR GeneID; 1026429; -.
DR GeneID; 66672654; -.
DR KEGG; sfl:SF3480; -.
DR KEGG; sfx:S4283; -.
DR PATRIC; fig|198214.7.peg.4101; -.
DR HOGENOM; CLU_073546_0_0_6; -.
DR OMA; ETGIMRL; -.
DR OrthoDB; 1653234at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0009276; C:Gram-negative-bacterium-type cell wall; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; ISS:UniProtKB.
DR InterPro; IPR004513; ABC_transpt_FtsX.
DR InterPro; IPR040690; FtsX_ECD.
DR PANTHER; PTHR47755; PTHR47755; 1.
DR Pfam; PF18075; FtsX_ECD; 1.
DR PIRSF; PIRSF003097; FtsX; 1.
DR TIGRFAMs; TIGR00439; ftsX; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..352
FT /note="Cell division protein FtsX"
FT /id="PRO_0000166799"
FT TOPO_DOM 1..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..223
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..275
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..322
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..352
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 19..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 352 AA; 38544 MW; C006ED56043739AE CRC64;
MNKRDAINHI RQFGGRLDRF RKSVGGSGDG GRNAPKRAKS SPKPVNRKTN VFNEQVRYAF
HGALQDLKSK PFATFLTVMV IAISLTLPSV CYMVYKNVNQ AATQYYPSPQ ITVYLQKTLD
DDAAAGVVAQ LQAEQGVEKV NYLSREDALG EFRNWSGFGG ALDMLEENPL PAVAVVIPKL
DFQGTESLNT LRDRITQING IDEVRMDDSW FARLAALTGL VGRVSAMIGV LMVAAVFLVI
GNSVRLSIFA RRDSINVQKL IGATDGFILR PFLYGGALLG FSGALLSLIL SEILVLRLSS
AVAEVAQVFG TKFDINGLSF DECLLLLLVC SMIGWVAAWL ATVQHLRHFT PE
