ID   FTSY_AQUAE              Reviewed;         461 AA.
AC   O67066;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Signal recognition particle receptor FtsY {ECO:0000255|HAMAP-Rule:MF_00920};
DE            Short=SRP receptor {ECO:0000255|HAMAP-Rule:MF_00920};
GN   Name=ftsY {ECO:0000255|HAMAP-Rule:MF_00920}; OrderedLocusNames=aq_920;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: Involved in targeting and insertion of nascent membrane
CC       proteins into the cytoplasmic membrane. Acts as a receptor for the
CC       complex formed by the signal recognition particle (SRP) and the
CC       ribosome-nascent chain (RNC). {ECO:0000255|HAMAP-Rule:MF_00920}.
CC   -!- SUBUNIT: Part of the signal recognition particle protein translocation
CC       system, which is composed of SRP and FtsY. {ECO:0000255|HAMAP-
CC       Rule:MF_00920}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein;
CC       Cytoplasmic side. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00920}.
CC   -!- SIMILARITY: Belongs to the GTP-binding SRP family. FtsY subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00920}.
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DR   EMBL; AE000657; AAC07030.1; -; Genomic_DNA.
DR   PIR; G70379; G70379.
DR   RefSeq; NP_213628.1; NC_000918.1.
DR   RefSeq; WP_010880566.1; NC_000918.1.
DR   AlphaFoldDB; O67066; -.
DR   SMR; O67066; -.
DR   STRING; 224324.aq_920; -.
DR   EnsemblBacteria; AAC07030; AAC07030; aq_920.
DR   KEGG; aae:aq_920; -.
DR   PATRIC; fig|224324.8.peg.721; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG0552; Bacteria.
DR   HOGENOM; CLU_009301_3_5_0; -.
DR   InParanoid; O67066; -.
DR   OMA; WLDDMEY; -.
DR   OrthoDB; 656414at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031226; C:intrinsic component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0005047; F:signal recognition particle binding; IBA:GO_Central.
DR   GO; GO:0006605; P:protein targeting; IBA:GO_Central.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 1.20.120.140; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00920; FtsY; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR   InterPro; IPR004390; SR_rcpt_FtsY.
DR   InterPro; IPR036225; SRP/SRP_N.
DR   InterPro; IPR000897; SRP54_GTPase_dom.
DR   InterPro; IPR042101; SRP54_N_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR43134:SF7; PTHR43134:SF7; 1.
DR   Pfam; PF00448; SRP54; 1.
DR   Pfam; PF02881; SRP54_N; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00962; SRP54; 1.
DR   SMART; SM00963; SRP54_N; 1.
DR   SMART; SM00028; TPR; 1.
DR   SUPFAM; SSF47364; SSF47364; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00064; ftsY; 1.
DR   PROSITE; PS00300; SRP54; 1.
DR   PROSITE; PS50005; TPR; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cytoplasm; GTP-binding; Membrane;
KW   Nucleotide-binding; Receptor; Reference proteome; TPR repeat.
FT   CHAIN           1..461
FT                   /note="Signal recognition particle receptor FtsY"
FT                   /id="PRO_0000101126"
FT   REPEAT          105..138
FT                   /note="TPR"
FT   BINDING         267..274
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00920"
FT   BINDING         349..353
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00920"
FT   BINDING         413..416
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00920"
SQ   SEQUENCE   461 AA;  51931 MW;  9D66F143849A662F CRC64;
     MVFFWRKSDV EKKAEKGDKN AILELIKQGK KEKAEKILKK YASQREDLAE LLFELYVQEG
     KLVQAYPLLK KYGDKIGKAK ERAKVYQAVG EYQKAIEEFL KVGDFESLYN VAKIYHQLEK
     PDKALEYAQR AEKLVPYEKK EELENFITQL KKELGLIEEK KESILDKLRR GLQKTKEAVE
     FGVLFRGRKV DEEFFEELEE MLVKADVGVK TAVELTEKLR KEAIRKNIKE GEKIKELLKK
     ELKELLKNCQ GELKIPEKVG AVLLFVGVNG SGKTTTIGKL AHQLKQKGKK VLLVAGDTFR
     AAAIEQLEVW AKRAGVDIVK KEEGSDPGAV VYEGMKKAKE EGYEVVLVDT AGRLHTKEPL
     INELRKIKKV IQKFDKEEPS ETLLVIDATT GQNAIQQAKV FKEAVDITGI VVTKLDGSAK
     GGAVVAICRE LKIPIKLVGV GEGIDDLQPF DADAYVEALL E