ID   FTSY_METH1              Reviewed;         351 AA.
AC   O32861; D1J8P7;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Signal recognition particle receptor FtsY {ECO:0000255|HAMAP-Rule:MF_00920};
DE            Short=SRP receptor {ECO:0000255|HAMAP-Rule:MF_00920};
GN   Name=ftsY {ECO:0000255|HAMAP-Rule:MF_00920}; OrderedLocusNames=MHO_4590;
OS   Metamycoplasma hominis (strain ATCC 23114 / DSM 25592 / NBRC 14850 / NCTC
OS   10111 / PG21) (Mycoplasma hominis).
OC   Bacteria; Tenericutes; Mycoplasmoidales; Metamycoplasmataceae;
OC   Metamycoplasma.
OX   NCBI_TaxID=347256;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Ladefoged S.A., Christiansen G.;
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23114 / DSM 25592 / NBRC 14850 / NCTC 10111 / PG21;
RX   PubMed=19816563; DOI=10.1371/journal.pgen.1000677;
RA   Pereyre S., Sirand-Pugnet P., Beven L., Charron A., Renaudin H., Barre A.,
RA   Avenaud P., Jacob D., Couloux A., Barbe V., de Daruvar A., Blanchard A.,
RA   Bebear C.;
RT   "Life on arginine for Mycoplasma hominis: clues from its minimal genome and
RT   comparison with other human urogenital mycoplasmas.";
RL   PLoS Genet. 5:E1000677-E1000677(2009).
CC   -!- FUNCTION: Involved in targeting and insertion of nascent membrane
CC       proteins into the cytoplasmic membrane. Acts as a receptor for the
CC       complex formed by the signal recognition particle (SRP) and the
CC       ribosome-nascent chain (RNC). {ECO:0000255|HAMAP-Rule:MF_00920}.
CC   -!- SUBUNIT: Part of the signal recognition particle protein translocation
CC       system, which is composed of SRP and FtsY. {ECO:0000255|HAMAP-
CC       Rule:MF_00920}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein;
CC       Cytoplasmic side. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00920}.
CC   -!- SIMILARITY: Belongs to the GTP-binding SRP family. FtsY subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00920}.
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DR   EMBL; Y11726; CAA72412.1; -; Genomic_DNA.
DR   EMBL; FP236530; CAX37594.1; -; Genomic_DNA.
DR   RefSeq; WP_012855733.1; NC_013511.1.
DR   AlphaFoldDB; O32861; -.
DR   SMR; O32861; -.
DR   STRING; 347256.MHO_4590; -.
DR   EnsemblBacteria; CAX37594; CAX37594; MHO_4590.
DR   KEGG; mho:MHO_4590; -.
DR   eggNOG; COG0552; Bacteria.
DR   HOGENOM; CLU_009301_3_4_14; -.
DR   OMA; GISDQFQ; -.
DR   OrthoDB; 656414at2; -.
DR   Proteomes; UP000002631; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031226; C:intrinsic component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 1.20.120.140; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00920; FtsY; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR   InterPro; IPR004390; SR_rcpt_FtsY.
DR   InterPro; IPR036225; SRP/SRP_N.
DR   InterPro; IPR000897; SRP54_GTPase_dom.
DR   InterPro; IPR042101; SRP54_N_sf.
DR   PANTHER; PTHR43134:SF7; PTHR43134:SF7; 1.
DR   Pfam; PF00448; SRP54; 1.
DR   Pfam; PF02881; SRP54_N; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00962; SRP54; 1.
DR   SMART; SM00963; SRP54_N; 1.
DR   SUPFAM; SSF47364; SSF47364; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00064; ftsY; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cytoplasm; GTP-binding; Membrane; Nucleotide-binding;
KW   Receptor; Reference proteome.
FT   CHAIN           1..351
FT                   /note="Signal recognition particle receptor FtsY"
FT                   /id="PRO_0000101136"
FT   BINDING         152..159
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00920"
FT   BINDING         235..239
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00920"
FT   BINDING         299..302
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00920"
SQ   SEQUENCE   351 AA;  39104 MW;  C230389AE4B51C9F CRC64;
     MGFWSNLKDK LFGTKEERIA KKQAKIEAKE QRQLEKELIK KNKLNTYIAG LSKSNSSFNE
     HIKELQNKHN KIDEEFFEDL EEMLIMSDIS IKLVQIIINE CKKEVRNENI TDPKLINEII
     ADKLFTIYTS NSVVDTTLNI KDNRLNVILV VGVNGSGKTT SISKIAKKLI DEGKKVLIAA
     GDTFRAAAVE QLEIWAKRVG ADIVTPNENE VDPAAVVYRA IDIAKSKKYD ILIVDTAGRL
     QNKVNLMNEL AKINRVLASK IPDAPHESLL VLDATTGQNG VIQARVFKES TPLTGIILTK
     MDGTSKGGIV LTIKDEIGLF VKYIGLGEKV DDLAEFDLDS YIYGLTKGIN E