FTSY_MYCMS
ID FTSY_MYCMS Reviewed; 400 AA.
AC Q6MTB9;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Signal recognition particle receptor FtsY {ECO:0000255|HAMAP-Rule:MF_00920};
DE Short=SRP receptor {ECO:0000255|HAMAP-Rule:MF_00920};
GN Name=ftsY {ECO:0000255|HAMAP-Rule:MF_00920}; OrderedLocusNames=MSC_0489;
OS Mycoplasma mycoides subsp. mycoides SC (strain PG1).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=272632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PG1;
RX PubMed=14762060; DOI=10.1101/gr.1673304;
RA Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J.,
RA Johansson K.-E., Pettersson B., Uhlen M.;
RT "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain
RT PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP).";
RL Genome Res. 14:221-227(2004).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 88-400.
RX PubMed=16343944; DOI=10.1016/j.jsb.2005.10.003;
RA Gariani T., Samuelsson T., Sauer-Eriksson A.E.;
RT "Conformational variability of the GTPase domain of the signal recognition
RT particle receptor FtsY.";
RL J. Struct. Biol. 153:85-96(2006).
CC -!- FUNCTION: Involved in targeting and insertion of nascent membrane
CC proteins into the cytoplasmic membrane. Acts as a receptor for the
CC complex formed by the signal recognition particle (SRP) and the
CC ribosome-nascent chain (RNC). {ECO:0000255|HAMAP-Rule:MF_00920}.
CC -!- SUBUNIT: Part of the signal recognition particle protein translocation
CC system, which is composed of SRP and FtsY. {ECO:0000255|HAMAP-
CC Rule:MF_00920}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein;
CC Cytoplasmic side. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00920}.
CC -!- SIMILARITY: Belongs to the GTP-binding SRP family. FtsY subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00920}.
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DR EMBL; BX293980; CAE77117.1; -; Genomic_DNA.
DR RefSeq; NP_975475.1; NC_005364.2.
DR PDB; 1ZU4; X-ray; 1.95 A; A=88-400.
DR PDB; 1ZU5; X-ray; 2.40 A; A/B=88-400.
DR PDBsum; 1ZU4; -.
DR PDBsum; 1ZU5; -.
DR AlphaFoldDB; Q6MTB9; -.
DR SMR; Q6MTB9; -.
DR STRING; 272632.MSC_0489; -.
DR EnsemblBacteria; CAE77117; CAE77117; MSC_0489.
DR KEGG; mmy:MSC_0489; -.
DR PATRIC; fig|272632.4.peg.529; -.
DR eggNOG; COG0552; Bacteria.
DR HOGENOM; CLU_009301_3_3_14; -.
DR OMA; GISDQFQ; -.
DR EvolutionaryTrace; Q6MTB9; -.
DR Proteomes; UP000001016; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031226; C:intrinsic component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR Gene3D; 1.20.120.140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00920; FtsY; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR InterPro; IPR004390; SR_rcpt_FtsY.
DR InterPro; IPR036225; SRP/SRP_N.
DR InterPro; IPR000897; SRP54_GTPase_dom.
DR InterPro; IPR042101; SRP54_N_sf.
DR PANTHER; PTHR43134:SF7; PTHR43134:SF7; 1.
DR Pfam; PF00448; SRP54; 1.
DR Pfam; PF02881; SRP54_N; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00962; SRP54; 1.
DR SMART; SM00963; SRP54_N; 1.
DR SUPFAM; SSF47364; SSF47364; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00064; ftsY; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Cytoplasm; GTP-binding; Membrane;
KW Nucleotide-binding; Receptor; Reference proteome.
FT CHAIN 1..400
FT /note="Signal recognition particle receptor FtsY"
FT /id="PRO_0000416703"
FT REGION 12..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 192..199
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00920"
FT BINDING 278..282
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00920"
FT BINDING 342..345
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00920"
FT HELIX 92..107
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 114..126
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 131..144
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 151..167
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 173..176
FT /evidence="ECO:0007829|PDB:1ZU5"
FT STRAND 186..193
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 198..211
FT /evidence="ECO:0007829|PDB:1ZU4"
FT STRAND 216..220
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 226..236
FT /evidence="ECO:0007829|PDB:1ZU4"
FT TURN 237..239
FT /evidence="ECO:0007829|PDB:1ZU4"
FT STRAND 244..247
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 256..269
FT /evidence="ECO:0007829|PDB:1ZU4"
FT STRAND 273..278
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 283..285
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 286..301
FT /evidence="ECO:0007829|PDB:1ZU4"
FT STRAND 309..316
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 317..320
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 321..330
FT /evidence="ECO:0007829|PDB:1ZU4"
FT TURN 331..333
FT /evidence="ECO:0007829|PDB:1ZU4"
FT STRAND 338..342
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 344..346
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 352..360
FT /evidence="ECO:0007829|PDB:1ZU4"
FT STRAND 364..368
FT /evidence="ECO:0007829|PDB:1ZU4"
FT STRAND 370..372
FT /evidence="ECO:0007829|PDB:1ZU4"
FT STRAND 376..378
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 381..388
FT /evidence="ECO:0007829|PDB:1ZU4"
FT HELIX 390..392
FT /evidence="ECO:0007829|PDB:1ZU4"
SQ SEQUENCE 400 AA; 45730 MW; E8ABED8D9BD99CAD CRC64;
MGFWAKLKEK LTKKTNQVEQ DEPILDQQDQ QDQQEEQEQI IEKEIEQIKE NKIKKTKTSE
TKKQEKPIET LKEKKKREKQ KEKDKKVEKA MLKSAFNFSK DIKKLSKKYK QADDEFFEEL
EDVLIQTDMG MKMVLKVSNL VRKKTKRDTS FENIKDALVE SLYQAYTDND WTNKKYRIDF
KENRLNIFML VGVNGTGKTT SLAKMANYYA ELGYKVLIAA ADTFRAGATQ QLEEWIKTRL
NNKVDLVKAN KLNADPASVV FDAIKKAKEQ NYDLLLIDTA GRLQNKVNLM AELEKMNKII
QQVEKSAPHE VLLVIDATTG QNGVIQAEEF SKVADVSGII LTKMDSTSKG GIGLAIKELL
NIPIKMIGVG EKVDDLLAFD IDQYIVHLSS GFMQGDEVEK
