ID   FTZ_DROHY               Reviewed;         456 AA.
AC   P48590;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Segmentation protein fushi tarazu;
GN   Name=ftz;
OS   Drosophila hydei (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7224;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Jost W., Yu Y., Pick L., Preiss A., Maier D.;
RL   Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in determining neuronal identity, may be
CC       directly involved in specifying identity of individual neurons.
CC       Required during embryogenesis for the process of body segmentation.
CC       Homeotic protein, required in alternating segment primordia, it
CC       specifies the correct number of segments (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- MISCELLANEOUS: 'Fushi tarazu' means 'segment deficient' in Japanese.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X79494; CAA56039.1; -; Genomic_DNA.
DR   PIR; S45137; S45137.
DR   AlphaFoldDB; P48590; -.
DR   SMR; P48590; -.
DR   PRIDE; P48590; -.
DR   FlyBase; FBgn0012391; Dhyd\ftz.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0007366; P:periodic partitioning by pair rule gene; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR005567; FTZ_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF03867; FTZ; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Pair-rule protein;
KW   Phosphoprotein; Transcription; Transcription regulation.
FT   CHAIN           1..456
FT                   /note="Segmentation protein fushi tarazu"
FT                   /id="PRO_0000049061"
FT   DNA_BIND        283..342
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          338..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        421..456
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   456 AA;  52011 MW;  C16C3099071086D8 CRC64;
     MAATNTHYYA DSMYNMYHHA LPPTYYDNTS SSSSYYQSSQ GWQPASYQGS SYAHYSQESY
     SESCYYANYH HQQQQQQHQD QPLCLPTLDA VPQYQVPTIA EPVIETSSPA PVKSRKRKAE
     ESAADIIAAV EERPSTLRAL LTNPVKKLKY TPDYFYTTIE HVKKPSKSSS AGELSPCYEQ
     DYAVPTPSTQ QTHMSPQRST GEDVDYLDVY SPRKQAKHGD FITPPPAATT PVDGIGITIS
     TPPQSPAEKS NEINHRIVTA ANSSNEFNWS HIEETIASDC KDSKRTRQTY SRYQTLELEK
     EFHFNRYITR RRRMDIAHAL NLSERQIKIW FQNRRMKSKK DRTLEASPDH CTTTGYASLL
     PPLDATAMPP QTQPQPQPHL QPAAAMPYAA YPAYLPATQQ SYDYPQQSPP PPHFAQPYDA
     QYTPQYHQQT QQQCSYQQQQ QQQELNTSNQ ALYHLP