FTZ_DROME
ID FTZ_DROME Reviewed; 410 AA.
AC P02835; O96929; Q4V6Y3; Q9V3W3;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2002, sequence version 2.
DT 03-AUG-2022, entry version 213.
DE RecName: Full=Segmentation protein fushi tarazu;
GN Name=ftz; ORFNames=CG2047;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=6330566; DOI=10.1038/310025a0;
RA Laughon A., Scott M.P.;
RT "Sequence of a Drosophila segmentation gene: protein structure homology
RT with DNA-binding proteins.";
RL Nature 310:25-31(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Berkeley;
RA Celniker S.E., Pfeiffer B., Knafels J., Martin C.H., Mayeda C.A.,
RA Palazzolo M.J.;
RT "Complete sequence of the Antennapedia complex of Drosophila.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 207-218, AND MUTAGENESIS.
RX PubMed=2276626; DOI=10.1101/gad.4.11.1936;
RA Kellerman K.A., Mattson D.M., Duncan I.;
RT "Mutations affecting the stability of the fushi tarazu protein of
RT Drosophila.";
RL Genes Dev. 4:1936-1950(1990).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 247-320.
RX PubMed=6327065; DOI=10.1016/0092-8674(84)90370-2;
RA McGinnis W., Garber R.L., Wirz J., Kuroiwa A., Gehring W.J.;
RT "A homologous protein-coding sequence in Drosophila homeotic genes and its
RT conservation in other metazoans.";
RL Cell 37:403-408(1984).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 250-320.
RX PubMed=6330741; DOI=10.1073/pnas.81.13.4115;
RA Scott M.P., Weiner A.J.;
RT "Structural relationships among genes that control development: sequence
RT homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of
RT Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 81:4115-4119(1984).
RN [9]
RP FUNCTION.
RX PubMed=2892267; DOI=10.1126/science.2892267;
RA Doe C.Q., Hiromi Y., Gehring W.J., Goodman C.S.;
RT "Expression and function of the segmentation gene fushi tarazu during
RT Drosophila neurogenesis.";
RL Science 239:170-175(1988).
RN [10]
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=3049237; DOI=10.1101/gad.2.8.1021;
RA Krause H.M., Klemenz R., Gehring W.J.;
RT "Expression, modification, and localization of the fushi tarazu protein in
RT Drosophila embryos.";
RL Genes Dev. 2:1021-1036(1988).
RN [11]
RP PHOSPHORYLATION.
RX PubMed=2743978; DOI=10.1002/j.1460-2075.1989.tb03492.x;
RA Krause H.M., Gehring W.J.;
RT "Stage-specific phosphorylation of the fushi tarazu protein during
RT Drosophila development.";
RL EMBO J. 8:1197-1204(1989).
RN [12]
RP STRUCTURE BY NMR OF HOMEOBOX.
RX PubMed=7909851; DOI=10.1006/jmbi.1994.1296;
RA Qian Y.Q., Furukubo-Tokunaga K., Resendez-Perez D., Mueller M.,
RA Gehring W.J., Wuethrich K.;
RT "Nuclear magnetic resonance solution structure of the fushi tarazu
RT homeodomain from Drosophila and comparison with the Antennapedia
RT homeodomain.";
RL J. Mol. Biol. 238:333-345(1994).
CC -!- FUNCTION: May play a role in determining neuronal identity, may be
CC directly involved in specifying identity of individual neurons.
CC Required during embryogenesis for the process of body segmentation.
CC Homeotic protein, required in alternating segment primordia, it
CC specifies the correct number of segments. {ECO:0000269|PubMed:2892267,
CC ECO:0000269|PubMed:3049237, ECO:0000269|PubMed:6330566}.
CC -!- INTERACTION:
CC P02835; P33244: ftz-f1; NbExp=3; IntAct=EBI-125786, EBI-160447;
CC P02835; P23758: Poxn; NbExp=3; IntAct=EBI-125786, EBI-105329;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:3049237}.
CC -!- TISSUE SPECIFICITY: Expressed early in development in a striped pattern
CC at the blastoderm stage. Later expressed in a specific subset of
CC neuronal precursor cells, neurons and glia in the developing CNS.
CC Between 5 and 6 hours of development, found in the midline precursor-2
CC cells in a segmentally repeating pattern. Expression in many other
CC neuronal precursors follows and reaches a second peak of abundance at 9
CC hours of development. Expressed in the hindgut between 11-15 hours of
CC development.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryonic development.
CC {ECO:0000269|PubMed:3049237}.
CC -!- PTM: Phosphorylated at as many as 16 sites.
CC {ECO:0000269|PubMed:2743978}.
CC -!- MISCELLANEOUS: 'Fushi tarazu' means 'segment deficient' in Japanese.
CC Flies lacking ftz exhibit embryos with half the usual number of body
CC segments.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; X00854; CAA25408.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF54081.1; -; Genomic_DNA.
DR EMBL; BT022173; AAY51567.1; -; mRNA.
DR EMBL; AE001572; AAD19794.1; -; Genomic_DNA.
DR EMBL; X78905; CAA55518.1; -; Genomic_DNA.
DR EMBL; K01947; AAA28372.1; -; Genomic_DNA.
DR PIR; A93334; WJFFFT.
DR RefSeq; NP_477498.1; NM_058150.3.
DR PDB; 1FTZ; NMR; -; A=253-321.
DR PDB; 2XHS; X-ray; 2.80 A; B=107-115.
DR PDBsum; 1FTZ; -.
DR PDBsum; 2XHS; -.
DR AlphaFoldDB; P02835; -.
DR SMR; P02835; -.
DR BioGRID; 66032; 29.
DR DIP; DIP-18500N; -.
DR IntAct; P02835; 14.
DR STRING; 7227.FBpp0081139; -.
DR iPTMnet; P02835; -.
DR PaxDb; P02835; -.
DR DNASU; 40834; -.
DR EnsemblMetazoa; FBtr0081625; FBpp0081139; FBgn0001077.
DR GeneID; 40834; -.
DR KEGG; dme:Dmel_CG2047; -.
DR CTD; 40834; -.
DR FlyBase; FBgn0001077; ftz.
DR VEuPathDB; VectorBase:FBgn0001077; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000175004; -.
DR HOGENOM; CLU_589608_0_0_1; -.
DR InParanoid; P02835; -.
DR OMA; CKDSKRT; -.
DR OrthoDB; 858478at2759; -.
DR PhylomeDB; P02835; -.
DR SignaLink; P02835; -.
DR BioGRID-ORCS; 40834; 0 hits in 1 CRISPR screen.
DR EvolutionaryTrace; P02835; -.
DR GenomeRNAi; 40834; -.
DR PRO; PR:P02835; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0001077; Expressed in parasegment (Drosophila) and 23 other tissues.
DR Genevisible; P02835; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0001708; P:cell fate specification; TAS:FlyBase.
DR GO; GO:0007417; P:central nervous system development; TAS:FlyBase.
DR GO; GO:0008354; P:germ cell migration; IMP:FlyBase.
DR GO; GO:0007506; P:gonadal mesoderm development; IMP:FlyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0007366; P:periodic partitioning by pair rule gene; TAS:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:FlyBase.
DR GO; GO:0035282; P:segmentation; IMP:FlyBase.
DR CDD; cd00086; homeodomain; 1.
DR IDEAL; IID50242; -.
DR InterPro; IPR005567; FTZ_N.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF03867; FTZ; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Pair-rule protein; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..410
FT /note="Segmentation protein fushi tarazu"
FT /id="PRO_0000049062"
FT DNA_BIND 254..313
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 71..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..207
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 208
FT /note="P->L: In allele Ual2; half-life is increased."
FT /evidence="ECO:0000269|PubMed:2276626"
FT MUTAGEN 212
FT /note="P->L: In allele Ual1; half-life is increased."
FT /evidence="ECO:0000269|PubMed:2276626"
FT MUTAGEN 212
FT /note="P->S: In allele Ual3; half-life is increased."
FT /evidence="ECO:0000269|PubMed:2276626"
FT CONFLICT 47
FT /note="Y -> YHSY (in Ref. 1; CAA25408)"
FT /evidence="ECO:0000305"
FT CONFLICT 141
FT /note="S -> T (in Ref. 1; CAA25408)"
FT /evidence="ECO:0000305"
FT CONFLICT 247..249
FT /note="LAS -> MLT (in Ref. 7; AAA28372)"
FT /evidence="ECO:0000305"
FT CONFLICT 395
FT /note="H -> Q (in Ref. 1; CAA25408)"
FT /evidence="ECO:0000305"
FT HELIX 108..113
FT /evidence="ECO:0007829|PDB:2XHS"
FT HELIX 263..273
FT /evidence="ECO:0007829|PDB:1FTZ"
FT HELIX 281..290
FT /evidence="ECO:0007829|PDB:1FTZ"
FT HELIX 295..305
FT /evidence="ECO:0007829|PDB:1FTZ"
FT HELIX 315..317
FT /evidence="ECO:0007829|PDB:1FTZ"
SQ SEQUENCE 410 AA; 46479 MW; 517154F3DAF8262F CRC64;
MATTNSQSHY SYADNMNMYN MYHPHSLPPT YYDNSGSNAY YQNTSNYQGY YPQESYSESC
YYYNNQEQVT TQTVPPVQPT TPPPKATKRK AEDDAASIIA AVEERPSTLR ALLTNPVKKL
KYTPDYFYTT VEQVKKAPAV STKVTASPAP SYDQEYVTVP TPSASEDVDY LDVYSPQSQT
QKLKNGDFAT PPPTTPTSLP PLEGISTPPQ SPGEKSSSAV SQEINHRIVT APNGAGDFNW
SHIEETLASD CKDSKRTRQT YTRYQTLELE KEFHFNRYIT RRRRIDIANA LSLSERQIKI
WFQNRRMKSK KDRTLDSSPE HCGAGYTAML PPLEATSTAT TGAPSVPVPM YHHHQTTAAY
PAYSHSHSHG YGLLNDYPQQ QTHQQYDAYP QQYQHQCSYQ QHPQDLYHLS
