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FUB12_GIBM7
ID   FUB12_GIBM7             Reviewed;         661 AA.
AC   W7MT41;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Fusaric acid cluster transcription factor FUB12 {ECO:0000303|PubMed:25372119};
DE   AltName: Full=Fusaric acid biosynthesis protein 12 {ECO:0000303|PubMed:25372119};
GN   Name=FUB12 {ECO:0000303|PubMed:25372119}; ORFNames=FVEG_12534;
OS   Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS   fungus) (Fusarium verticillioides).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=334819;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M3125 / FGSC 7600;
RX   PubMed=20237561; DOI=10.1038/nature08850;
RA   Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA   Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA   Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA   Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA   Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA   Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA   Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA   Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA   Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA   Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA   Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA   Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT   "Comparative genomics reveals mobile pathogenicity chromosomes in
RT   Fusarium.";
RL   Nature 464:367-373(2010).
RN   [2]
RP   BIOTECHNOLOGY.
RX   PubMed=16868776; DOI=10.1007/s00425-006-0345-6;
RA   Samadi L., Shahsavan Behboodi B.;
RT   "Fusaric acid induces apoptosis in saffron root-tip cells: roles of
RT   caspase-like activity, cytochrome c, and H2O2.";
RL   Planta 225:223-234(2006).
RN   [3]
RP   BIOTECHNOLOGY.
RX   PubMed=17927749; DOI=10.1111/j.1365-2672.2007.03581.x;
RA   Son S.W., Kim H.Y., Choi G.J., Lim H.K., Jang K.S., Lee S.O., Lee S.,
RA   Sung N.D., Kim J.C.;
RT   "Bikaverin and fusaric acid from Fusarium oxysporum show antioomycete
RT   activity against Phytophthora infestans.";
RL   J. Appl. Microbiol. 104:692-698(2008).
RN   [4]
RP   BIOTECHNOLOGY.
RX   PubMed=21811925; DOI=10.1007/s12272-011-0716-9;
RA   Pan J.H., Chen Y., Huang Y.H., Tao Y.W., Wang J., Li Y., Peng Y., Dong T.,
RA   Lai X.M., Lin Y.C.;
RT   "Antimycobacterial activity of fusaric acid from a mangrove endophyte and
RT   its metal complexes.";
RL   Arch. Pharm. Res. 34:1177-1181(2011).
RN   [5]
RP   BIOTECHNOLOGY.
RX   PubMed=20955724; DOI=10.1016/j.toxicon.2010.10.006;
RA   Stipanovic R.D., Puckhaber L.S., Liu J., Bell A.A.;
RT   "Phytotoxicity of fusaric acid and analogs to cotton.";
RL   Toxicon 57:176-178(2011).
RN   [6]
RP   INDUCTION.
RX   PubMed=22713715; DOI=10.1016/j.fgb.2012.06.003;
RA   Butchko R.A., Brown D.W., Busman M., Tudzynski B., Wiemann P.;
RT   "Lae1 regulates expression of multiple secondary metabolite gene clusters
RT   in Fusarium verticillioides.";
RL   Fungal Genet. Biol. 49:602-612(2012).
RN   [7]
RP   BIOTECHNOLOGY.
RX   PubMed=22864988; DOI=10.1055/s-0032-1315146;
RA   Boonman N., Prachya S., Boonmee A., Kittakoop P., Wiyakrutta S.,
RA   Sriubolmas N., Warit S., Dharmkrong-At Chusattayanond A.;
RT   "In vitro acanthamoebicidal activity of fusaric acid and dehydrofusaric
RT   acid from an endophytic fungus Fusarium sp. Tlau3.";
RL   Planta Med. 78:1562-1567(2012).
RN   [8]
RP   BIOTECHNOLOGY.
RX   PubMed=23838885; DOI=10.1007/s00425-013-1928-7;
RA   Jiao J., Zhou B., Zhu X., Gao Z., Liang Y.;
RT   "Fusaric acid induction of programmed cell death modulated through nitric
RT   oxide signalling in tobacco suspension cells.";
RL   Planta 238:727-737(2013).
RN   [9]
RP   BIOTECHNOLOGY.
RX   PubMed=23922960; DOI=10.1371/journal.pone.0070226;
RA   Li C., Zuo C., Deng G., Kuang R., Yang Q., Hu C., Sheng O., Zhang S.,
RA   Ma L., Wei Y., Yang J., Liu S., Biswas M.K., Viljoen A., Yi G.;
RT   "Contamination of bananas with beauvericin and fusaric acid produced by
RT   Fusarium oxysporum f. sp. cubense.";
RL   PLoS ONE 8:E70226-E70226(2013).
RN   [10]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=25372119; DOI=10.1094/mpmi-09-14-0264-r;
RA   Brown D.W., Lee S.H., Kim L.H., Ryu J.G., Lee S., Seo Y., Kim Y.H.,
RA   Busman M., Yun S.H., Proctor R.H., Lee T.;
RT   "Identification of a 12-gene fusaric acid biosynthetic gene cluster in
RT   Fusarium species through comparative and functional genomics.";
RL   Mol. Plant Microbe Interact. 28:319-332(2015).
CC   -!- FUNCTION: Transcription factor that is involved in the formation of the
CC       two Fusaric acid derivatives, dehydrofusaric acid and fusarinolic acid,
CC       serving as a detoxification mechanism (By similarity).
CC       {ECO:0000250|UniProtKB:S0DRX3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- INDUCTION: Expression is positively regulated by the secondary
CC       metabolism regulator LAE1 (PubMed:22713715).
CC       {ECO:0000269|PubMed:22713715}.
CC   -!- DISRUPTION PHENOTYPE: Substantially reduces production of fusaric acid
CC       (PubMed:25372119). {ECO:0000269|PubMed:25372119}.
CC   -!- BIOTECHNOLOGY: Fusaric acid is phytotoxic to plants such as cotton and
CC       banana (PubMed:20955724, PubMed:23922960). It has been shown to induce
CC       programmed cell death in plants (PubMed:16868776, PubMed:23838885). In
CC       addition to a mild toxicity to animals, fusaric acid exhibits
CC       acanthamoebicidal, antioomycete, and antimycobacterial activities
CC       (PubMed:17927749, PubMed:22864988, PubMed:21811925).
CC       {ECO:0000269|PubMed:16868776, ECO:0000269|PubMed:17927749,
CC       ECO:0000269|PubMed:20955724, ECO:0000269|PubMed:21811925,
CC       ECO:0000269|PubMed:22864988, ECO:0000269|PubMed:23838885,
CC       ECO:0000269|PubMed:23922960}.
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DR   EMBL; DS022261; EWG54281.1; -; Genomic_DNA.
DR   RefSeq; XP_018760472.1; XM_018901877.1.
DR   AlphaFoldDB; W7MT41; -.
DR   SMR; W7MT41; -.
DR   EnsemblFungi; FVEG_12534T0; FVEG_12534T0; FVEG_12534.
DR   GeneID; 30069967; -.
DR   KEGG; fvr:FVEG_12534; -.
DR   VEuPathDB; FungiDB:FVEG_12534; -.
DR   eggNOG; ENOG502SIT4; Eukaryota.
DR   HOGENOM; CLU_023926_1_0_1; -.
DR   OMA; RRIWWVL; -.
DR   OrthoDB; 739059at2759; -.
DR   PHI-base; PHI:3380; -.
DR   Proteomes; UP000009096; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..661
FT                   /note="Fusaric acid cluster transcription factor FUB12"
FT                   /id="PRO_0000437331"
FT   DNA_BIND        17..48
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          56..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          151..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..98
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   661 AA;  74808 MW;  C5C845F48F8C3830 CRC64;
     MPLPSRASST PKISKACVPC RTRKIKCNAA VVGLPCGSCV SRECPDECVL SARKRRTVKG
     RNAETPRSRK NIPDTNGSVL SPRQQQLPTN VSRQATDSSH SDPVEESIHA SHTGSSLRND
     TPHSRDRRPP GQTQADLLYL NILQDTVNDT SAAQTDASDH QSNDEPDDSF NSQIHHWNPP
     PQLDDVDNEY LAKKKVFELP PPRFMENIVK AYFDYVHPFA PILNRTDFIQ SYRSGSCCLF
     LLHAVAAAAS LYVTHDVLIG CGYQDRSTAQ ASFFSKAKLF HDFHCQGDPL SMLQGSMILG
     AIILDHPSDR DFQYWFHNSV RRASKMGVQN ACLRDDGSQK LYRRIWWVLH NRDIFHFFIN
     TQNMRLLANA PPIRPLTEAD WETEDMEQWS GILSPISQAQ KVSLIAQCEL AQIFGNVMSV
     VTSSTPSAEE IHKRILPLDA WRTSLPERMQ LMASFANGEK YHLEALTTSY RFECIMCRLL
     RRGRWQMSDG GLREWAQQRF RSAIFELDTI VKRVMINNTI QKLPTTFITT ITALLALHIE
     SALDAAESSL IRSMARISVQ HTMLALDQIR DTPAIKRALP AFEIVLSKNK LYPMSTSDTE
     QISTIQTIPQ DQTLSDGQIL QPPPTDMTLP QDDQSFLYGD FIGFDFLDRW QMEQLDFTGI
     Y
 
 
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