FUC10_CAEEL
ID FUC10_CAEEL Reviewed; 363 AA.
AC Q968A5; Q18747;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=GDP-fucose transporter;
DE AltName: Full=Nucleotide sugar transporter protein 10 {ECO:0000312|WormBase:C50F4.14a};
GN Name=nstp-10 {ECO:0000312|WormBase:C50F4.14a};
GN ORFNames=C50F4.14 {ECO:0000312|WormBase:C50F4.14a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=Bristol N2;
RX PubMed=11326279; DOI=10.1038/ng0501-69;
RA Luehn K., Wild M.K., Eckhardt M., Gerardy-Schahn R., Vestweber D.;
RT "The gene defective in leukocyte adhesion deficiency II encodes a putative
RT GDP-fucose transporter.";
RL Nat. Genet. 28:69-72(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Involved in GDP-fucose import from the cytoplasm into the
CC Golgi lumen. {ECO:0000269|PubMed:11326279}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:11326279}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:9851916}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35C subfamily.
CC {ECO:0000305}.
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DR EMBL; AF323969; AAK50396.1; -; mRNA.
DR EMBL; Z70750; CAA94748.2; -; Genomic_DNA.
DR PIR; T20120; T20120.
DR RefSeq; NP_001263841.1; NM_001276912.1.
DR AlphaFoldDB; Q968A5; -.
DR SMR; Q968A5; -.
DR STRING; 6239.C50F4.14a; -.
DR PaxDb; Q968A5; -.
DR EnsemblMetazoa; C50F4.14a.1; C50F4.14a.1; WBGene00008237.
DR GeneID; 179342; -.
DR KEGG; cel:CELE_C50F4.14; -.
DR UCSC; C50F4.14; c. elegans.
DR CTD; 179342; -.
DR WormBase; C50F4.14a; CE30910; WBGene00008237; nstp-10.
DR eggNOG; KOG1442; Eukaryota.
DR GeneTree; ENSGT00390000013315; -.
DR InParanoid; Q968A5; -.
DR OMA; GLQIKYT; -.
DR OrthoDB; 870214at2759; -.
DR PhylomeDB; Q968A5; -.
DR Reactome; R-CEL-6787639; GDP-fucose biosynthesis.
DR Reactome; R-CEL-727802; Transport of nucleotide sugars.
DR PRO; PR:Q968A5; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00008237; Expressed in adult organism and 4 other tissues.
DR ExpressionAtlas; Q968A5; baseline and differential.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005457; F:GDP-fucose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0036085; P:GDP-fucose import into Golgi lumen; IBA:GO_Central.
DR GO; GO:0036066; P:protein O-linked fucosylation; IBA:GO_Central.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..363
FT /note="GDP-fucose transporter"
FT /id="PRO_0000213392"
FT TRANSMEM 30..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 334..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 363 AA; 40401 MW; 69B9B0E5686FA1BE CRC64;
MKLHEENNKA LFEAMRNREN PTKWESYKQV ITAVSAYWVF SIGLVFLNKY LLSSVQLDAP
LFITWYQCLV TVFLCLFLSK TSKAYGLFKF PSMPIDAKIS REVLPLSVVF VAMISFNNLC
LKYVGVSFYY VGRSLTTVFN VVCTYLILGQ KTSGQAIGCC ALIIFGFLLG VDQEGVTGTL
SYTGVIFGVL ASLSVALNAI YTRKVLSSVG DCLWRLTMYN NLNALVLFLP LMLFNGEFGA
VFYFDKLFDT TFWILMTLGG VFGFMMGYVT GWQIQATSPL THNISGTAKA AAQTVMAVVW
YSELKTLLWW TSNFVVLFGS GMYTYVQKRV MDKKNSGASP ASEAKSDKVK LLGRDGNAAE
ESV
