ID   FUCK_HAEIN              Reviewed;         470 AA.
AC   P44399;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=L-fuculokinase {ECO:0000255|HAMAP-Rule:MF_00986};
DE            EC=2.7.1.51 {ECO:0000255|HAMAP-Rule:MF_00986};
DE   AltName: Full=L-fuculose kinase {ECO:0000255|HAMAP-Rule:MF_00986};
GN   Name=fucK {ECO:0000255|HAMAP-Rule:MF_00986}; OrderedLocusNames=HI_0613;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Catalyzes the phosphorylation of L-fuculose.
CC       {ECO:0000255|HAMAP-Rule:MF_00986}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-fuculose = ADP + H(+) + L-fuculose 1-phosphate;
CC         Xref=Rhea:RHEA:12376, ChEBI:CHEBI:15378, ChEBI:CHEBI:17617,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:57846, ChEBI:CHEBI:456216;
CC         EC=2.7.1.51; Evidence={ECO:0000255|HAMAP-Rule:MF_00986};
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00986};
CC   -!- PATHWAY: Carbohydrate degradation; L-fucose degradation; L-lactaldehyde
CC       and glycerone phosphate from L-fucose: step 2/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00986}.
CC   -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000255|HAMAP-
CC       Rule:MF_00986}.
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DR   EMBL; L42023; AAC22272.1; -; Genomic_DNA.
DR   PIR; E64081; E64081.
DR   RefSeq; NP_438771.1; NC_000907.1.
DR   RefSeq; WP_005694547.1; NC_000907.1.
DR   AlphaFoldDB; P44399; -.
DR   SMR; P44399; -.
DR   STRING; 71421.HI_0613; -.
DR   EnsemblBacteria; AAC22272; AAC22272; HI_0613.
DR   KEGG; hin:HI_0613; -.
DR   PATRIC; fig|71421.8.peg.637; -.
DR   eggNOG; COG1070; Bacteria.
DR   HOGENOM; CLU_009281_11_2_6; -.
DR   OMA; SDLWMQI; -.
DR   PhylomeDB; P44399; -.
DR   BioCyc; HINF71421:G1GJ1-634-MON; -.
DR   UniPathway; UPA00563; UER00625.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008737; F:L-fuculokinase activity; IBA:GO_Central.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IBA:GO_Central.
DR   GO; GO:0042355; P:L-fucose catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0019301; P:rhamnose catabolic process; IBA:GO_Central.
DR   HAMAP; MF_00986; Fuculokinase; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018485; Carb_kinase_FGGY_C.
DR   InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR   InterPro; IPR018484; Carb_kinase_FGGY_N.
DR   InterPro; IPR013450; Fuculokinase.
DR   PANTHER; PTHR10196:SF60; PTHR10196:SF60; 1.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   PIRSF; PIRSF000538; GlpK; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02628; fuculo_kin_coli; 1.
DR   PROSITE; PS00933; FGGY_KINASES_1; 1.
DR   PROSITE; PS00445; FGGY_KINASES_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Fucose metabolism; Kinase;
KW   Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..470
FT                   /note="L-fuculokinase"
FT                   /id="PRO_0000059425"
SQ   SEQUENCE   470 AA;  51949 MW;  9FAEE26213E9AB7A CRC64;
     MAIALIFDCG ATNLRTIAIN EKGQILASHH LANNTKQGIE SSDYHIWDIE EIWQKLTSCA
     TQTLNQLMQQ GIDLKDIVGI SVTTFGVDGA PFDENDQQLY PIISWKCPRT IPVMENLSNQ
     LDIKSLYQRN GIGQYSFNTL FKLHWLKTHK PDVFQKMAKF VFISSMLTQR LTGQFTTDHT
     MAGTSMMTNL TSGNWDPSIL ASLGLSNNHF PPMRYAGEKV GKLRTPLAQK WGLNPVPVIS
     CGHDTQFAVF GSGAGLNQPV LSSGTWEILM ARTQHAEPRF EFVSQGLTTE FDAQSNCFNP
     AVQWVGSGVI EWLGKLLFSD VYGSDHYYTT MIKEGEKAFN AGKRAVNFEG IFSQLGQGNI
     SGLSMFATRG EIYVSALQHM ANKLKNGLSV LHQVSQFQAK SLICVGGGSK NVLWNQIRAN
     TLNLPIDVVD ISESTVLGAA MFTFAGVGIY ENVNAAQQAM QPTRKRIYPN