FUCL7_ANGJA
ID FUCL7_ANGJA Reviewed; 189 AA.
AC Q9I925;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Fucolectin-7;
DE Flags: Precursor;
OS Anguilla japonica (Japanese eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC Anguilla.
OX NCBI_TaxID=7937;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAB03529.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Gill {ECO:0000312|EMBL:BAB03529.1};
RX PubMed=10924498; DOI=10.1074/jbc.m002337200;
RA Honda S., Kashiwagi M., Miyamoto K., Takei Y., Hirose S.;
RT "Multiplicity, structures, and endocrine and exocrine natures of eel
RT fucose-binding lectins.";
RL J. Biol. Chem. 275:33151-33157(2000).
CC -!- FUNCTION: Acts as a defensive agent. Recognizes blood group fucosylated
CC oligosaccharides including A, B, H and Lewis B-type antigens. Does not
CC recognize Lewis A antigen and has low affinity for monovalent haptens.
CC {ECO:0000269|PubMed:10924498}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:Q7SIC1}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10924498}.
CC -!- TISSUE SPECIFICITY: Gill mucous cells. {ECO:0000269|PubMed:10924498}.
CC -!- MISCELLANEOUS: Binds 1 calcium ion per monomer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the fucolectin family. {ECO:0000305}.
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DR EMBL; AB037873; BAB03529.1; -; mRNA.
DR AlphaFoldDB; Q9I925; -.
DR SMR; Q9I925; -.
DR CAZy; CBM47; Carbohydrate-Binding Module Family 47.
DR PRIDE; Q9I925; -.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR GO; GO:0030246; F:carbohydrate binding; IDA:UniProtKB.
DR GO; GO:0042806; F:fucose binding; IDA:UniProtKB.
DR GO; GO:0010185; P:regulation of cellular defense response; TAS:UniProtKB.
DR GO; GO:0001868; P:regulation of complement activation, lectin pathway; TAS:UniProtKB.
DR GO; GO:0045088; P:regulation of innate immune response; TAS:UniProtKB.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR006585; FTP1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR SMART; SM00607; FTP; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
PE 2: Evidence at transcript level;
KW Calcium; Disulfide bond; Lectin; Metal-binding; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..189
FT /note="Fucolectin-7"
FT /evidence="ECO:0000305"
FT /id="PRO_0000223938"
FT REGION 40..188
FT /note="F5/8 type C-like"
FT MOTIF 110..112
FT /note="Cell attachment site"
FT /evidence="ECO:0000255"
FT BINDING 67
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 70
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250|UniProtKB:Q7SIC1"
FT BINDING 72
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 81
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250|UniProtKB:Q7SIC1"
FT BINDING 84
FT /ligand="alpha-L-fucose"
FT /ligand_id="ChEBI:CHEBI:42548"
FT /evidence="ECO:0000250|UniProtKB:Q7SIC1"
FT BINDING 110
FT /ligand="alpha-L-fucose"
FT /ligand_id="ChEBI:CHEBI:42548"
FT /evidence="ECO:0000250|UniProtKB:Q7SIC1"
FT BINDING 117
FT /ligand="alpha-L-fucose"
FT /ligand_id="ChEBI:CHEBI:42548"
FT /evidence="ECO:0000250|UniProtKB:Q7SIC1"
FT BINDING 177
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 178
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250|UniProtKB:Q7SIC1"
FT DISULFID 82..177
FT /evidence="ECO:0000250|UniProtKB:Q7SIC1"
FT DISULFID 113..114
FT /evidence="ECO:0000250|UniProtKB:Q7SIC1"
FT DISULFID 139..155
FT /evidence="ECO:0000250|UniProtKB:Q7SIC1"
SQ SEQUENCE 189 AA; 20894 MW; 457A11F2FA9432E0 CRC64;
MKTCNLTDRM EVKMIMLLFQ ILAISTLKSD SADIPEGYIQ ENVALRGRAT QSAQLRGDHS
GIAHASNAID GNRDSVFYHG SCTHTEADKP WWRVDLLQVY TITSVTITNR GDCCEERISG
ARILIGKHLE NNGINNPQCS VIGPMAAGET KTFRCPQPMI GRYVTVYLPK AESLHLCEVE
VNVLFPAPC