FUCM_DANRE
ID FUCM_DANRE Reviewed; 153 AA.
AC Q7ZZ03;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Fucose mutarotase;
DE EC=5.1.3.29;
GN Name=fuom; ORFNames=si:ch211-217g15.2, zgc:101698;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the interconversion between alpha- and beta-L-
CC fucoses. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-L-fucose = beta-L-fucose; Xref=Rhea:RHEA:25580,
CC ChEBI:CHEBI:42548, ChEBI:CHEBI:42589; EC=5.1.3.29;
CC -!- SIMILARITY: Belongs to the RbsD / FucU family. {ECO:0000305}.
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DR EMBL; AL831745; CAD60840.1; -; Genomic_DNA.
DR EMBL; BC081387; AAH81387.1; -; mRNA.
DR RefSeq; NP_001004530.1; NM_001004530.1.
DR RefSeq; XP_005156875.1; XM_005156818.3.
DR RefSeq; XP_017214222.1; XM_017358733.1.
DR AlphaFoldDB; Q7ZZ03; -.
DR SMR; Q7ZZ03; -.
DR STRING; 7955.ENSDARP00000057598; -.
DR PaxDb; Q7ZZ03; -.
DR Ensembl; ENSDART00000057599; ENSDARP00000057598; ENSDARG00000039422.
DR GeneID; 447896; -.
DR KEGG; dre:447896; -.
DR CTD; 282969; -.
DR ZFIN; ZDB-GENE-030616-618; fuom.
DR eggNOG; ENOG502RZR7; Eukaryota.
DR GeneTree; ENSGT00390000001197; -.
DR HOGENOM; CLU_120075_1_0_1; -.
DR InParanoid; Q7ZZ03; -.
DR OMA; MGHGDDI; -.
DR OrthoDB; 1457717at2759; -.
DR PhylomeDB; Q7ZZ03; -.
DR TreeFam; TF324689; -.
DR Reactome; R-DRE-6787639; GDP-fucose biosynthesis.
DR PRO; PR:Q7ZZ03; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 13.
DR Bgee; ENSDARG00000039422; Expressed in liver and 25 other tissues.
DR GO; GO:0042806; F:fucose binding; ISS:UniProtKB.
DR GO; GO:0036373; F:L-fucose mutarotase activity; IEA:UniProtKB-EC.
DR GO; GO:0016857; F:racemase and epimerase activity, acting on carbohydrates and derivatives; ISS:UniProtKB.
DR GO; GO:0006004; P:fucose metabolic process; ISS:UniProtKB.
DR GO; GO:0036065; P:fucosylation; IBA:GO_Central.
DR Gene3D; 3.40.1650.10; -; 1.
DR InterPro; IPR023750; RbsD-like_sf.
DR InterPro; IPR007721; RbsD_FucU.
DR Pfam; PF05025; RbsD_FucU; 1.
DR SUPFAM; SSF102546; SSF102546; 1.
PE 2: Evidence at transcript level;
KW Isomerase; Reference proteome.
FT CHAIN 1..153
FT /note="Fucose mutarotase"
FT /id="PRO_0000286555"
FT ACT_SITE 24
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT ACT_SITE 69
FT /evidence="ECO:0000250"
FT ACT_SITE 119
FT /evidence="ECO:0000250"
FT BINDING 32
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 78
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 119
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 137
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 139
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 153 AA; 16677 MW; AFD5AEC4BA9B679F CRC64;
MVILKGIPSV LTPELLYVLA QMGHGDELVL ADANFPTSSV CKCGPVEIRA DGVRIPELLK
AILKLFPLDT YDESAAVMDL VPSDLLKGLK VPIWDQYSEL LKQAGSDGNM KPVERFAFYE
RAKKAFAVVA TGETALYGNL IIKKGVIPPE EQC
