FUCM_HAEIN
ID FUCM_HAEIN Reviewed; 144 AA.
AC P44778;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=L-fucose mutarotase {ECO:0000255|HAMAP-Rule:MF_01662};
DE EC=5.1.3.29 {ECO:0000255|HAMAP-Rule:MF_01662};
DE AltName: Full=Fucose 1-epimerase {ECO:0000255|HAMAP-Rule:MF_01662};
DE AltName: Full=Type-2 mutarotase {ECO:0000255|HAMAP-Rule:MF_01662};
GN Name=fucU {ECO:0000255|HAMAP-Rule:MF_01662}; OrderedLocusNames=HI_0612;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Involved in the anomeric conversion of L-fucose.
CC {ECO:0000255|HAMAP-Rule:MF_01662}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-L-fucose = beta-L-fucose; Xref=Rhea:RHEA:25580,
CC ChEBI:CHEBI:42548, ChEBI:CHEBI:42589; EC=5.1.3.29;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01662};
CC -!- PATHWAY: Carbohydrate metabolism; L-fucose metabolism.
CC {ECO:0000255|HAMAP-Rule:MF_01662}.
CC -!- SUBUNIT: Homodecamer. {ECO:0000255|HAMAP-Rule:MF_01662}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01662}.
CC -!- SIMILARITY: Belongs to the RbsD / FucU family. FucU mutarotase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01662}.
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DR EMBL; L42023; AAC22271.1; -; Genomic_DNA.
DR PIR; D64081; D64081.
DR RefSeq; NP_438770.1; NC_000907.1.
DR RefSeq; WP_005648572.1; NC_000907.1.
DR AlphaFoldDB; P44778; -.
DR SMR; P44778; -.
DR STRING; 71421.HI_0612; -.
DR EnsemblBacteria; AAC22271; AAC22271; HI_0612.
DR KEGG; hin:HI_0612; -.
DR PATRIC; fig|71421.8.peg.636; -.
DR eggNOG; COG4154; Bacteria.
DR HOGENOM; CLU_120075_1_0_6; -.
DR OMA; MGHGDDI; -.
DR PhylomeDB; P44778; -.
DR BioCyc; HINF71421:G1GJ1-633-MON; -.
DR UniPathway; UPA00956; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042806; F:fucose binding; IBA:GO_Central.
DR GO; GO:0036373; F:L-fucose mutarotase activity; IEA:UniProtKB-EC.
DR GO; GO:0016857; F:racemase and epimerase activity, acting on carbohydrates and derivatives; IBA:GO_Central.
DR GO; GO:0006004; P:fucose metabolic process; IBA:GO_Central.
DR GO; GO:0036065; P:fucosylation; IBA:GO_Central.
DR GO; GO:0042354; P:L-fucose metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1650.10; -; 1.
DR HAMAP; MF_01662; L_fucose_rotase; 1.
DR InterPro; IPR023751; L-fucose_mutarotase.
DR InterPro; IPR023750; RbsD-like_sf.
DR InterPro; IPR007721; RbsD_FucU.
DR Pfam; PF05025; RbsD_FucU; 1.
DR SUPFAM; SSF102546; SSF102546; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Cytoplasm; Fucose metabolism; Isomerase;
KW Reference proteome.
FT CHAIN 1..144
FT /note="L-fucose mutarotase"
FT /id="PRO_0000087383"
FT ACT_SITE 22
FT /note="Proton donor"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01662"
FT BINDING 30
FT /ligand="substrate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01662"
FT BINDING 109
FT /ligand="substrate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01662"
FT BINDING 131..133
FT /ligand="substrate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01662"
SQ SEQUENCE 144 AA; 15750 MW; 3665520CDB7935B2 CRC64;
MLKGIHPALS PELLKTLAEM GHGDEIVLAD AHFPAHSLHK NVIRADGISI DILLEAITPL
FEFDAYVDAP LLMMKAVEGD SLDPNVETRY LNAIESAVGF TPNLTCLERF DFYTRAKQAY
AVVVSGEIAK YGNIIIKKGV TPIL
