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FUCM_SALTY
ID   FUCM_SALTY              Reviewed;         140 AA.
AC   Q8ZMC4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=L-fucose mutarotase {ECO:0000255|HAMAP-Rule:MF_01662};
DE            EC=5.1.3.29 {ECO:0000255|HAMAP-Rule:MF_01662};
DE   AltName: Full=Fucose 1-epimerase {ECO:0000255|HAMAP-Rule:MF_01662};
DE   AltName: Full=Type-2 mutarotase {ECO:0000255|HAMAP-Rule:MF_01662};
GN   Name=fucU {ECO:0000255|HAMAP-Rule:MF_01662}; OrderedLocusNames=STM2978;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Involved in the anomeric conversion of L-fucose.
CC       {ECO:0000255|HAMAP-Rule:MF_01662}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-L-fucose = beta-L-fucose; Xref=Rhea:RHEA:25580,
CC         ChEBI:CHEBI:42548, ChEBI:CHEBI:42589; EC=5.1.3.29;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01662};
CC   -!- PATHWAY: Carbohydrate metabolism; L-fucose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_01662}.
CC   -!- SUBUNIT: Homodecamer. {ECO:0000255|HAMAP-Rule:MF_01662}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01662}.
CC   -!- SIMILARITY: Belongs to the RbsD / FucU family. FucU mutarotase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01662}.
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DR   EMBL; AE006468; AAL21856.1; -; Genomic_DNA.
DR   RefSeq; NP_461897.1; NC_003197.2.
DR   RefSeq; WP_000920845.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZMC4; -.
DR   SMR; Q8ZMC4; -.
DR   STRING; 99287.STM2978; -.
DR   PaxDb; Q8ZMC4; -.
DR   EnsemblBacteria; AAL21856; AAL21856; STM2978.
DR   GeneID; 1254501; -.
DR   KEGG; stm:STM2978; -.
DR   PATRIC; fig|99287.12.peg.3154; -.
DR   HOGENOM; CLU_120075_1_0_6; -.
DR   OMA; MGHGDDI; -.
DR   PhylomeDB; Q8ZMC4; -.
DR   BioCyc; SENT99287:STM2978-MON; -.
DR   UniPathway; UPA00956; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042806; F:fucose binding; IBA:GO_Central.
DR   GO; GO:0036373; F:L-fucose mutarotase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016857; F:racemase and epimerase activity, acting on carbohydrates and derivatives; IBA:GO_Central.
DR   GO; GO:0006004; P:fucose metabolic process; IBA:GO_Central.
DR   GO; GO:0036065; P:fucosylation; IBA:GO_Central.
DR   GO; GO:0042354; P:L-fucose metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1650.10; -; 1.
DR   HAMAP; MF_01662; L_fucose_rotase; 1.
DR   InterPro; IPR023751; L-fucose_mutarotase.
DR   InterPro; IPR023750; RbsD-like_sf.
DR   InterPro; IPR007721; RbsD_FucU.
DR   Pfam; PF05025; RbsD_FucU; 1.
DR   SUPFAM; SSF102546; SSF102546; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Fucose metabolism; Isomerase;
KW   Reference proteome.
FT   CHAIN           1..140
FT                   /note="L-fucose mutarotase"
FT                   /id="PRO_1000187203"
FT   ACT_SITE        22
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01662"
FT   BINDING         30
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01662"
FT   BINDING         107
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01662"
FT   BINDING         129..131
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01662"
SQ   SEQUENCE   140 AA;  15281 MW;  E512468640C2F30D CRC64;
     MLKTISPLIS PTLLKVLAEM GHGDEIIFSD AHFPAHSLGP QVIRADGLSV SDLLRAIIPL
     FELDSYAPPL VMMAAVEGDT LDPNVEARYR DALSLEAPCP DIVRIDRYAF YERAQKAFAI
     VITGECAKYG NILLKKGVTP
 
 
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