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ALFL6_ARATH
ID   ALFL6_ARATH             Reviewed;         256 AA.
AC   Q8S8M9; F4IQE0; Q8LAH0;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=PHD finger protein ALFIN-LIKE 6;
DE            Short=Protein AL6;
GN   Name=AL6; OrderedLocusNames=At2g02470; ORFNames=T16F16.26;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=19154204; DOI=10.1111/j.1365-313x.2009.03795.x;
RA   Lee W.Y., Lee D., Chung W.I., Kwon C.S.;
RT   "Arabidopsis ING and Alfin1-like protein families localize to the nucleus
RT   and bind to H3K4me3/2 via plant homeodomain fingers.";
RL   Plant J. 58:511-524(2009).
CC   -!- FUNCTION: Histone-binding component that specifically recognizes H3
CC       tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription
CC       start sites of virtually all active genes. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with H3K4me3 and to a lesser extent with H3K4me2.
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8S8M9-2; Q8GXR6: At3g58630/F14P22_220; NbExp=3; IntAct=EBI-15223069, EBI-4457957;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19154204}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8S8M9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8S8M9-2; Sequence=VSP_041817;
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC       {ECO:0000269|PubMed:19154204}.
CC   -!- DOMAIN: The PHD-type zinc finger mediates the binding to H3K4me3.
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
CC       site. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Alfin family. {ECO:0000305}.
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DR   EMBL; AC005312; AAM15031.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC05583.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC05584.1; -; Genomic_DNA.
DR   EMBL; BT003905; AAO41953.1; -; mRNA.
DR   EMBL; BT005004; AAO50537.1; -; mRNA.
DR   EMBL; AY087820; AAM65374.1; -; mRNA.
DR   PIR; A84437; A84437.
DR   PIR; T00616; T00616.
DR   RefSeq; NP_001189502.1; NM_001202573.2. [Q8S8M9-2]
DR   RefSeq; NP_178351.1; NM_126302.3. [Q8S8M9-1]
DR   AlphaFoldDB; Q8S8M9; -.
DR   SMR; Q8S8M9; -.
DR   BioGRID; 179; 12.
DR   IntAct; Q8S8M9; 3.
DR   STRING; 3702.AT2G02470.1; -.
DR   iPTMnet; Q8S8M9; -.
DR   PaxDb; Q8S8M9; -.
DR   PRIDE; Q8S8M9; -.
DR   ProteomicsDB; 245068; -. [Q8S8M9-1]
DR   EnsemblPlants; AT2G02470.1; AT2G02470.1; AT2G02470. [Q8S8M9-1]
DR   EnsemblPlants; AT2G02470.2; AT2G02470.2; AT2G02470. [Q8S8M9-2]
DR   GeneID; 814776; -.
DR   Gramene; AT2G02470.1; AT2G02470.1; AT2G02470. [Q8S8M9-1]
DR   Gramene; AT2G02470.2; AT2G02470.2; AT2G02470. [Q8S8M9-2]
DR   KEGG; ath:AT2G02470; -.
DR   Araport; AT2G02470; -.
DR   TAIR; locus:2056281; AT2G02470.
DR   eggNOG; KOG1632; Eukaryota.
DR   InParanoid; Q8S8M9; -.
DR   OMA; PSKMVKM; -.
DR   PhylomeDB; Q8S8M9; -.
DR   PRO; PR:Q8S8M9; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q8S8M9; baseline and differential.
DR   Genevisible; Q8S8M9; AT.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0042393; F:histone binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0016036; P:cellular response to phosphate starvation; IMP:TAIR.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0055065; P:metal ion homeostasis; IMP:TAIR.
DR   GO; GO:0048767; P:root hair elongation; IMP:TAIR.
DR   CDD; cd15613; PHD_AL_plant; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR045104; Alfin.
DR   InterPro; IPR021998; Alfin_N.
DR   InterPro; IPR044104; PHD_AL_plant.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12321; PTHR12321; 1.
DR   Pfam; PF12165; Alfin; 1.
DR   Pfam; PF00628; PHD; 1.
DR   SMART; SM00249; PHD; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Chromatin regulator; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..256
FT                   /note="PHD finger protein ALFIN-LIKE 6"
FT                   /id="PRO_0000412933"
FT   ZN_FING         200..252
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   REGION          144..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..173
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..199
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            210
FT                   /note="Histone H3K4me3 binding"
FT                   /evidence="ECO:0000250"
FT   SITE            216
FT                   /note="Histone H3K4me3 binding"
FT                   /evidence="ECO:0000250"
FT   SITE            220
FT                   /note="Histone H3K4me3 binding"
FT                   /evidence="ECO:0000250"
FT   SITE            225
FT                   /note="Histone H3K4me3 binding"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         162..170
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041817"
FT   CONFLICT        170
FT                   /note="S -> T (in Ref. 4; AAM65374)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   256 AA;  28847 MW;  9A033A5355BE4953 CRC64;
     MEGITHPIPR TVEEVFSDFR GRRAGLIKAL TNDMVKFYQT CDPEKENLCL YGLPNETWEV
     NLPVEEVPPE LPEPALGINF ARDGMQEKDW VSLVAVHSDS WLLSVAFYFG ARFGFGKNER
     KRLFQMINEL PTIFEVVSGN AKQSKDLSVN NNNSKSKPSG VKSRQSESLS KVAKMSSPPP
     KEEEEEEDES EDESEDDEQG AVCGACGDNY GTDEFWICCD ACEKWFHGKC VKITPAKAEH
     IKHYKCPTCS NKRARP
 
 
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