ID   FUCP_HAEIN              Reviewed;         428 AA.
AC   P44776;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=L-fucose-proton symporter {ECO:0000250|UniProtKB:P11551};
DE   AltName: Full=L-fucose-H(+) symport protein {ECO:0000250|UniProtKB:P11551};
GN   Name=fucP; OrderedLocusNames=HI_0610;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Mediates the uptake of L-fucose across the boundary membrane
CC       with the concomitant transport of protons into the cell (symport
CC       system). {ECO:0000250|UniProtKB:P11551}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + L-fucose(in) = H(+)(out) + L-fucose(out);
CC         Xref=Rhea:RHEA:29023, ChEBI:CHEBI:2181, ChEBI:CHEBI:15378;
CC         Evidence={ECO:0000250|UniProtKB:P11551};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29025;
CC         Evidence={ECO:0000250|UniProtKB:P11551};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P11551}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P11551}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. FHS
CC       transporter (TC 2.A.1.7) family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22269.1; -; Genomic_DNA.
DR   PIR; B64081; B64081.
DR   RefSeq; NP_438768.1; NC_000907.1.
DR   RefSeq; WP_005694544.1; NC_000907.1.
DR   AlphaFoldDB; P44776; -.
DR   SMR; P44776; -.
DR   STRING; 71421.HI_0610; -.
DR   EnsemblBacteria; AAC22269; AAC22269; HI_0610.
DR   KEGG; hin:HI_0610; -.
DR   PATRIC; fig|71421.8.peg.634; -.
DR   eggNOG; COG0738; Bacteria.
DR   HOGENOM; CLU_028452_0_1_6; -.
DR   OMA; TWGFAYG; -.
DR   PhylomeDB; P44776; -.
DR   BioCyc; HINF71421:G1GJ1-631-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015535; F:fucose:proton symporter activity; IEA:InterPro.
DR   GO; GO:0006004; P:fucose metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR005275; Lfuc_symporter_FucP.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00885; fucP; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cell inner membrane; Cell membrane;
KW   Fucose metabolism; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..428
FT                   /note="L-fucose-proton symporter"
FT                   /id="PRO_0000094502"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   428 AA;  46988 MW;  93893FD9DC4EFB2F CRC64;
     MNAKVLEKKF IVPFVLITSL FALWGFANDI TNPMVAVFQT VMEIPASEAA LVQLAFYGGY
     GTMAIPAALF ASRYSYKAGI LLGLALYAIG AFLFWPAAQY EIFNFFLVSL YILTFGLAFL
     ETTANPYILA MGDPQTATRR LNFAQSFNPL GSITGMFVAS QLVLTNLESD KRDAAGNLIF
     HTLSEAEKMS IRTHDLAEIR DPYIALGFVV VAVFIIIGLK KMPAVKIEEA GQISFKTAVS
     RLAQKAKYRE GVIAQAFYVG VQIMCWTFIV QYAERLGFTK AEGQNFNIIA MAIFISSRFI
     STALMKYLKA EFMLMLFAIG GFLSILGVIF IDGVWGLYCL ILTSGFMPLM FPTIYGIALY
     GLKEESTLGA AGLVMAIVGG ALMPPLQGMI IDQGEVMGLP AVNFSFILPL ICFVVIAIYG
     FRAWKILK