ID   FUJ3_GIBF5              Reviewed;         320 AA.
AC   S0EBV2;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Polyketide transferase FFUJ_12241 {ECO:0000305};
DE            EC=2.3.-.- {ECO:0000305};
DE   AltName: Full=Fujikurins biosynthesis cluster protein FFUJ_12241 {ECO:0000303|PubMed:26192387};
GN   ORFNames=FFUJ_12241;
OS   Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS   and foot rot disease fungus) (Fusarium fujikuroi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=1279085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION, FUNCTION,
RP   AND INDUCTION.
RC   STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831;
RX   PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA   Wiemann P., Sieber C.M.K., von Bargen K.W., Studt L., Niehaus E.-M.,
RA   Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA   Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA   Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA   Proctor R.H., Muensterkoetter M., Freitag M., Humpf H.-U., Gueldener U.,
RA   Tudzynski B.;
RT   "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT   Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT   novel metabolites.";
RL   PLoS Pathog. 9:E1003475-E1003475(2013).
RN   [2]
RP   FUNCTION.
RX   PubMed=26192387; DOI=10.1021/np5008137;
RA   von Bargen K.W., Niehaus E.M., Krug I., Bergander K., Wuerthwein E.U.,
RA   Tudzynski B., Humpf H.U.;
RT   "Isolation and structure elucidation of fujikurins A-D: products of the
RT   PKS19 gene cluster in Fusarium fujikuroi.";
RL   J. Nat. Prod. 78:1809-1815(2015).
CC   -!- FUNCTION: Polyketide transferase; part of the gene cluster that
CC       mediates the biosynthesis of fujikurins A-D, secondary metabolites
CC       playing a role during rice infection (PubMed:23825955,
CC       PubMed:26192387). The polyketide synthase PKS19 acts with the trans-
CC       enoyl reductase FFUJ_12240 and the polyketide transferase FFUJ_12241 to
CC       produce fujikurins, however, the biosynthesis pathway has not been
CC       identified yet (PubMed:23825955, PubMed:26192387).
CC       {ECO:0000269|PubMed:23825955, ECO:0000269|PubMed:26192387}.
CC   -!- INDUCTION: The fujikurins gene cluster is specifically expressed during
CC       rice infection (PubMed:23825955). {ECO:0000269|PubMed:23825955}.
CC   -!- SIMILARITY: Belongs to the polyketide transferase af380 family.
CC       {ECO:0000305}.
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DR   EMBL; HF679030; CCT72379.1; -; Genomic_DNA.
DR   AlphaFoldDB; S0EBV2; -.
DR   SMR; S0EBV2; -.
DR   STRING; 5127.CCT72379; -.
DR   ESTHER; gibf5-fuj3; Thiohydrolase.
DR   EnsemblFungi; CCT72379; CCT72379; FFUJ_12241.
DR   VEuPathDB; FungiDB:FFUJ_12241; -.
DR   HOGENOM; CLU_048587_1_1_1; -.
DR   Proteomes; UP000016800; Chromosome 8.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   Pfam; PF12697; Abhydrolase_6; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Transferase.
FT   CHAIN           1..320
FT                   /note="Polyketide transferase FFUJ_12241"
FT                   /id="PRO_0000442007"
FT   REGION          58..298
FT                   /note="Abhydrolase domain"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   320 AA;  35736 MW;  72CA51689BCB8F9F CRC64;
     MSPVLPRHDI EFPTLDGITL RGWLYPATKR GPGMILSPGF NMPKDAIIPD ICKWFQERDI
     TCLAWDPRGI GASDGEPRND IDPRQEAEHL HDAVTWLSKN PLVDVTKIAL WGLCFGGNVT
     LAAAALEYVL NGSPFSSPPC FVVPSWADID LTLSKRIAAM ISVAPLIDST GLPERRQPIL
     ELAMYDRAGR LEGDDPMYLP YVNEDGSVPN GLQLAADMMP ALDRLGIPVE NRVTVQTYYR
     ALTWSVLNLV EYIAPTPAMM VTPEFDVSCP TKDQLKAYER MGEPKELDIL KGKGHLDWIF
     GDVDIILNRQ LDFLKRQMNF