ID   FUMD_SALTI              Reviewed;          70 AA.
AC   P0A1T5; Q9Z4T1;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Fumarase D {ECO:0000250|UniProtKB:P0ACX5};
DE            EC=4.2.1.2 {ECO:0000250|UniProtKB:P0ACX5};
GN   Name=fumD {ECO:0000250|UniProtKB:P0ACX5}; Synonyms=ydhZ;
GN   OrderedLocusNames=STY1732, t1256;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: In vitro catalyzes the addition of water to fumarate, forming
CC       malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer
CC       maleate as substrate. {ECO:0000250|UniProtKB:P0ACX5}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate = fumarate + H2O; Xref=Rhea:RHEA:12460,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15589, ChEBI:CHEBI:29806; EC=4.2.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P0ACX5};
CC   -!- SIMILARITY: Belongs to the FumD family. {ECO:0000305}.
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DR   EMBL; AL513382; CAD01977.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO68908.1; -; Genomic_DNA.
DR   RefSeq; NP_456140.1; NC_003198.1.
DR   RefSeq; WP_000165779.1; NZ_WSUR01000011.1.
DR   AlphaFoldDB; P0A1T5; -.
DR   SMR; P0A1T5; -.
DR   STRING; 220341.16502819; -.
DR   EnsemblBacteria; AAO68908; AAO68908; t1256.
DR   KEGG; stt:t1256; -.
DR   KEGG; sty:STY1732; -.
DR   PATRIC; fig|220341.7.peg.1743; -.
DR   eggNOG; ENOG50347SK; Bacteria.
DR   HOGENOM; CLU_2755438_0_0_6; -.
DR   OMA; ALYQEMC; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR024493; FumD.
DR   Pfam; PF10965; DUF2767; 1.
PE   3: Inferred from homology;
KW   Lyase.
FT   CHAIN           1..70
FT                   /note="Fumarase D"
FT                   /id="PRO_0000168986"
SQ   SEQUENCE   70 AA;  7947 MW;  FE4C661F8F0DFA39 CRC64;
     MTKPTKDDEL YREMCRVVGK VVLEMRDLGQ EPKYIVIAGV LRTALANQRI QRSALEKQAM
     ETVINALARS