ID   FUMD_SALTY              Reviewed;          70 AA.
AC   P0A1T4; Q9Z4T1;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Fumarase D {ECO:0000250|UniProtKB:P0ACX5};
DE            EC=4.2.1.2 {ECO:0000250|UniProtKB:P0ACX5};
GN   Name=fumD {ECO:0000250|UniProtKB:P0ACX5}; Synonyms=ydhZ;
GN   OrderedLocusNames=STM1388;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=10231485; DOI=10.1046/j.1365-2958.1999.01345.x;
RA   Hensel M., Hinsley A.P., Nikolaus T., Sawers G., Berks B.C.;
RT   "The genetic basis of tetrathionate respiration in Salmonella
RT   typhimurium.";
RL   Mol. Microbiol. 32:275-287(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: In vitro catalyzes the addition of water to fumarate, forming
CC       malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer
CC       maleate as substrate. {ECO:0000250|UniProtKB:P0ACX5}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate = fumarate + H2O; Xref=Rhea:RHEA:12460,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15589, ChEBI:CHEBI:29806; EC=4.2.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P0ACX5};
CC   -!- SIMILARITY: Belongs to the FumD family. {ECO:0000305}.
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DR   EMBL; AJ224978; CAB37411.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20312.1; -; Genomic_DNA.
DR   RefSeq; NP_460353.1; NC_003197.2.
DR   RefSeq; WP_000165779.1; NC_003197.2.
DR   AlphaFoldDB; P0A1T4; -.
DR   SMR; P0A1T4; -.
DR   STRING; 99287.STM1388; -.
DR   PaxDb; P0A1T4; -.
DR   EnsemblBacteria; AAL20312; AAL20312; STM1388.
DR   GeneID; 1252906; -.
DR   KEGG; stm:STM1388; -.
DR   PATRIC; fig|99287.12.peg.1471; -.
DR   HOGENOM; CLU_2755438_0_0_6; -.
DR   OMA; ALYQEMC; -.
DR   PhylomeDB; P0A1T4; -.
DR   BioCyc; SENT99287:STM1388-MON; -.
DR   PHI-base; PHI:603; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR024493; FumD.
DR   Pfam; PF10965; DUF2767; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..70
FT                   /note="Fumarase D"
FT                   /id="PRO_0000168987"
SQ   SEQUENCE   70 AA;  7947 MW;  FE4C661F8F0DFA39 CRC64;
     MTKPTKDDEL YREMCRVVGK VVLEMRDLGQ EPKYIVIAGV LRTALANQRI QRSALEKQAM
     ETVINALARS