FUN14_YEAST
ID FUN14_YEAST Reviewed; 198 AA.
AC P18411; D6VPL0;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 3.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Protein FUN14;
GN Name=FUN14; OrderedLocusNames=YAL008W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=7941740; DOI=10.1002/yea.320100413;
RA Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B.,
RA Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.;
RT "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42
RT kbp SPO7-CENI-CDC15 region.";
RL Yeast 10:535-541(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7731988; DOI=10.1073/pnas.92.9.3809;
RA Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N.,
RA Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J.,
RA Storms R.K.;
RT "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-74.
RX PubMed=2253888; DOI=10.1016/0378-1119(90)90414-m;
RA Whyte W., Koepp L.H., Lamb J., Crowley J.C., Kaback D.B.;
RT "Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae:
RT isolation, characterization and regulation of the SPO7 sporulation gene.";
RL Gene 95:65-72(1990).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 1920 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the FUN14 family. {ECO:0000305}.
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DR EMBL; L05146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; L22015; AAC04950.1; -; Genomic_DNA.
DR EMBL; AY557707; AAS56033.1; -; Genomic_DNA.
DR EMBL; M36073; AAA35074.2; -; Genomic_DNA.
DR EMBL; BK006935; DAA06980.1; -; Genomic_DNA.
DR PIR; S43447; S43447.
DR RefSeq; NP_009394.1; NM_001178153.1.
DR AlphaFoldDB; P18411; -.
DR BioGRID; 31758; 36.
DR IntAct; P18411; 3.
DR MINT; P18411; -.
DR STRING; 4932.YAL008W; -.
DR MaxQB; P18411; -.
DR PaxDb; P18411; -.
DR PRIDE; P18411; -.
DR EnsemblFungi; YAL008W_mRNA; YAL008W; YAL008W.
DR GeneID; 851225; -.
DR KEGG; sce:YAL008W; -.
DR SGD; S000000006; FUN14.
DR VEuPathDB; FungiDB:YAL008W; -.
DR HOGENOM; CLU_1379105_0_0_1; -.
DR InParanoid; P18411; -.
DR OMA; GWIRINL; -.
DR BioCyc; YEAST:G3O-28821-MON; -.
DR Reactome; R-SCE-8934903; Receptor Mediated Mitophagy.
DR PRO; PR:P18411; -.
DR Proteomes; UP000002311; Chromosome I.
DR RNAct; P18411; protein.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IDA:SGD.
DR GO; GO:0005741; C:mitochondrial outer membrane; HDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; IGI:SGD.
DR GO; GO:0055091; P:phospholipid homeostasis; IGI:SGD.
DR InterPro; IPR007014; FUN14.
DR PANTHER; PTHR21346; PTHR21346; 1.
DR Pfam; PF04930; FUN14; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..198
FT /note="Protein FUN14"
FT /id="PRO_0000202412"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 198 AA; 22063 MW; F2AB77E54D53C791 CRC64;
MTLAFNMQRL VFRNLNVGKR MFKNVPLWRF NVANKLGKPL TRSVGLGGAG IVAGGFYLMN
RQPSKLIFND SLGAAVKQQG PLEPTVGNST AITEERRNKI SSHKQMFLGS LFGVVLGVTV
AKISILFMYV GITSMLLCEW LRYKGWIRIN LKNIKSVIVL KDVDLKKLLI DGLLGTEYMG
FKVFFTLSFV LASLNANK
