FUN19_YEAST
ID FUN19_YEAST Reviewed; 413 AA.
AC P28003; D6VPI4;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 3.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=SWIRM domain-containing protein FUN19;
GN Name=FUN19; OrderedLocusNames=YAL034C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1583694; DOI=10.1016/0022-2836(92)91025-k;
RA Harris S.D., Cheng J., Pugh T.A., Pringle J.R.;
RT "Molecular analysis of Saccharomyces cerevisiae chromosome I. On the number
RT of genes and the identification of essential genes using temperature-
RT sensitive-lethal mutations.";
RL J. Mol. Biol. 225:53-65(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7731988; DOI=10.1073/pnas.92.9.3809;
RA Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N.,
RA Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J.,
RA Storms R.K.;
RT "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995).
RN [3]
RP SEQUENCE REVISION.
RA Vo D.T.;
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP IDENTIFICATION OF PROBABLE INITIATION SITE.
RX PubMed=12748633; DOI=10.1038/nature01644;
RA Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.;
RT "Sequencing and comparison of yeast species to identify genes and
RT regulatory elements.";
RL Nature 423:241-254(2003).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-194; SER-207 AND SER-211, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- MISCELLANEOUS: FUN19 is a non-essential gene.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC04998.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA44456.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X62577; CAA44456.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U12980; AAC04998.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK006935; DAA06954.1; -; Genomic_DNA.
DR PIR; S23410; S23410.
DR RefSeq; NP_009368.2; NM_001180035.1.
DR AlphaFoldDB; P28003; -.
DR SMR; P28003; -.
DR BioGRID; 31732; 129.
DR DIP; DIP-6766N; -.
DR IntAct; P28003; 26.
DR MINT; P28003; -.
DR STRING; 4932.YAL034C; -.
DR iPTMnet; P28003; -.
DR MaxQB; P28003; -.
DR PaxDb; P28003; -.
DR PRIDE; P28003; -.
DR TopDownProteomics; P28003; -.
DR EnsemblFungi; YAL034C_mRNA; YAL034C; YAL034C.
DR GeneID; 851199; -.
DR KEGG; sce:YAL034C; -.
DR SGD; S000002134; FUN19.
DR VEuPathDB; FungiDB:YAL034C; -.
DR eggNOG; ENOG502R6VN; Eukaryota.
DR GeneTree; ENSGT00940000176451; -.
DR HOGENOM; CLU_042442_0_0_1; -.
DR InParanoid; P28003; -.
DR OMA; YRYATHG; -.
DR BioCyc; YEAST:G3O-28891-MON; -.
DR Reactome; R-SCE-5689880; Ub-specific processing proteases.
DR PRO; PR:P28003; -.
DR Proteomes; UP000002311; Chromosome I.
DR RNAct; P28003; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070461; C:SAGA-type complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0035066; P:positive regulation of histone acetylation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007526; SWIRM.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF04433; SWIRM; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50934; SWIRM; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..413
FT /note="SWIRM domain-containing protein FUN19"
FT /id="PRO_0000202417"
FT DOMAIN 316..413
FT /note="SWIRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00247"
FT REGION 35..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 194
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18407956"
FT MOD_RES 207
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956,
FT ECO:0007744|PubMed:19779198"
FT MOD_RES 211
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956"
FT CONFLICT 255
FT /note="T -> S (in Ref. 1; CAA44456)"
FT /evidence="ECO:0000305"
FT CONFLICT 369
FT /note="L -> S (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 413 AA; 47068 MW; B588358DBCF7A9AB CRC64;
MGLYSPESEK SQLNMNYIGK DDSQSIFRRL NQNLKASNNN NDSNKNGLNM SDYSNNSPYG
RSYDVRINQN SQNNGNGCFS GSIDSLVDEH IIPSPPLSPK LESKISHNGS PRMASSVLVG
STPKGAVENV LFVKPVWPNG LSRKRYRYAT YGFLSQYKIF SNLAQPYSKN IINRYNNLAY
NARHKYSKYN DDMTPPPLPS SSSRLPSPLA SPNLNRQARY NMRKQALYNN NLGKFESDTE
WIPRKRKVYS PQRRTMTTSP HRAKKFSPSA STPHTNIASI EAIHDAPQYI PNVSWKKLPD
YSPPLSTLPT DSNKSLKIEW KGSPMDLSTD PLRNELHPAE LVLAQTLRLP CDLYLDSKRR
LFLEKVYRLK KGLPFRRTDA QKACRIDVNK ASRLFQAFEK VGWLQDSNFT KYL
