ID   FUND1_BOVIN             Reviewed;         155 AA.
AC   F1N5S9; A6QQX3;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=FUN14 domain-containing protein 1;
GN   Name=FUNDC1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as an activator of hypoxia-induced mitophagy, an
CC       important mechanism for mitochondrial quality control. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via YXXL motif) with MAP1 LC3 family proteins
CC       MAP1LC3A, MAP1LC3B and GABARAP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- DOMAIN: The YXXL motif mediates the interaction with MAP1 LC3 family
CC       proteins MAP1LC3A, MAP1LC3B and GABARAP. {ECO:0000250}.
CC   -!- PTM: Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy.
CC       Following hypoxia, dephosphorylated at Tyr-18, leading to interaction
CC       with MAP1 LC3 family proteins and triggering mitophagy (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FUN14 family. {ECO:0000305}.
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DR   EMBL; DAAA02073542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC150029; AAI50030.1; -; mRNA.
DR   RefSeq; NP_001098452.1; NM_001104982.1.
DR   AlphaFoldDB; F1N5S9; -.
DR   SMR; F1N5S9; -.
DR   STRING; 9913.ENSBTAP00000002144; -.
DR   PaxDb; F1N5S9; -.
DR   PRIDE; F1N5S9; -.
DR   Ensembl; ENSBTAT00000002144; ENSBTAP00000002144; ENSBTAG00000001637.
DR   GeneID; 518258; -.
DR   KEGG; bta:518258; -.
DR   CTD; 139341; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001637; -.
DR   VGNC; VGNC:29143; FUNDC1.
DR   eggNOG; KOG4099; Eukaryota.
DR   GeneTree; ENSGT00940000154517; -.
DR   HOGENOM; CLU_095425_2_0_1; -.
DR   InParanoid; F1N5S9; -.
DR   OMA; ATVDHRE; -.
DR   OrthoDB; 1431148at2759; -.
DR   TreeFam; TF300280; -.
DR   Reactome; R-BTA-8934903; Receptor Mediated Mitophagy.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000001637; Expressed in adenohypophysis and 105 other tissues.
DR   GO; GO:0031307; C:integral component of mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0000422; P:autophagy of mitochondrion; ISS:UniProtKB.
DR   GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
DR   InterPro; IPR007014; FUN14.
DR   PANTHER; PTHR21346; PTHR21346; 1.
DR   Pfam; PF04930; FUN14; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..155
FT                   /note="FUN14 domain-containing protein 1"
FT                   /id="PRO_0000416275"
FT   TOPO_DOM        1..47
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..74
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..133
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        155
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   MOTIF           18..21
FT                   /note="YXXL"
FT   MOD_RES         13
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IVP5"
FT   MOD_RES         18
FT                   /note="Phosphotyrosine; by SRC"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IVP5"
FT   CONFLICT        113
FT                   /note="I -> V (in Ref. 2; AAI50030)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   155 AA;  17173 MW;  AB9F3271D5BC7CAF CRC64;
     MATRNPPPQE YESDDDSYEV LDLTEYARRH HWWNRVFGHS SGPMVEKYSV ATQIVMGGVS
     GWCAGFLFQK VGKLAATAVG GGFLLLQIAS HSGYVQIDWK RVEKDVNKAK RQIKKRANKA
     APEINNIIEE ATEFVKQNIV ISSGFVGGFL LGLAS