FUND1_DANRE
ID FUND1_DANRE Reviewed; 152 AA.
AC Q6DH87; B8A5Q6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 2.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=FUN14 domain-containing protein 1;
GN Name=fundc1; ORFNames=si:ch211-222m21.2, zgc:92600;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as an activator of hypoxia-induced mitophagy, an
CC important mechanism for mitochondrial quality control. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FUN14 family. {ECO:0000305}.
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DR EMBL; BX572627; CAX15484.1; -; Genomic_DNA.
DR EMBL; BC076092; AAH76092.1; -; mRNA.
DR RefSeq; NP_001002711.2; NM_001002711.2.
DR AlphaFoldDB; Q6DH87; -.
DR STRING; 7955.ENSDARP00000059836; -.
DR PaxDb; Q6DH87; -.
DR Ensembl; ENSDART00000059837; ENSDARP00000059836; ENSDARG00000040822.
DR GeneID; 436984; -.
DR KEGG; dre:436984; -.
DR CTD; 139341; -.
DR ZFIN; ZDB-GENE-040718-466; fundc1.
DR eggNOG; KOG4099; Eukaryota.
DR GeneTree; ENSGT00940000154517; -.
DR HOGENOM; CLU_095425_2_0_1; -.
DR InParanoid; Q6DH87; -.
DR OMA; ATVDHRE; -.
DR OrthoDB; 1431148at2759; -.
DR PhylomeDB; Q6DH87; -.
DR TreeFam; TF300280; -.
DR Reactome; R-DRE-8934903; Receptor Mediated Mitophagy.
DR PRO; PR:Q6DH87; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000040822; Expressed in brain and 37 other tissues.
DR ExpressionAtlas; Q6DH87; baseline.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:ZFIN.
DR GO; GO:0000422; P:autophagy of mitochondrion; ISS:UniProtKB.
DR GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
DR InterPro; IPR007014; FUN14.
DR PANTHER; PTHR21346; PTHR21346; 1.
DR Pfam; PF04930; FUN14; 1.
PE 2: Evidence at transcript level;
KW Autophagy; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..152
FT /note="FUN14 domain-containing protein 1"
FT /id="PRO_0000271348"
FT TRANSMEM 45..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 15..18
FT /note="YXXL"
FT CONFLICT 72
FT /note="V -> M (in Ref. 2; AAH76092)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 152 AA; 16744 MW; AB93DB50500BC4A1 CRC64;
MADRGEDAES EDELYEVVNI TDYARRHQWW SRVFGNSTGP IAEKYSVASQ IMMGGVSGWC
AGYLFQRVGK LVATAVGGGF LLLQIANHSG YVQVDWRKVE KDVNKAKKHL KKNAKKAAPE
LNTFIEDSTE FVKRNIVISG GFVGGFLLGL AS
