ID   FUND1_TETNG             Reviewed;         158 AA.
AC   Q4RY26;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=FUN14 domain-containing protein 1;
GN   Name=fundc1; ORFNames=GSTENG00027182001;
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- FUNCTION: Acts as an activator of hypoxia-induced mitophagy, an
CC       important mechanism for mitochondrial quality control. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FUN14 family. {ECO:0000305}.
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DR   EMBL; CAAE01014978; CAG06706.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4RY26; -.
DR   STRING; 99883.ENSTNIP00000017566; -.
DR   Ensembl; ENSTNIT00000017786; ENSTNIP00000017566; ENSTNIG00000014542.
DR   KEGG; tng:GSTEN00027182G001; -.
DR   GeneTree; ENSGT00940000154517; -.
DR   HOGENOM; CLU_095425_2_0_1; -.
DR   InParanoid; Q4RY26; -.
DR   OMA; ATVDHRE; -.
DR   TreeFam; TF300280; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0031307; C:integral component of mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0000422; P:autophagy of mitochondrion; ISS:UniProtKB.
DR   GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
DR   InterPro; IPR007014; FUN14.
DR   PANTHER; PTHR21346; PTHR21346; 1.
DR   Pfam; PF04930; FUN14; 1.
PE   3: Inferred from homology;
KW   Autophagy; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..158
FT                   /note="FUN14 domain-containing protein 1"
FT                   /id="PRO_0000271349"
FT   TRANSMEM        51..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           21..24
FT                   /note="YXXL"
SQ   SEQUENCE   158 AA;  17376 MW;  ADA7DB9F2B054CB5 CRC64;
     MATVDHREAG QDDPESEDEV YEVVDLTEYA RRHQWWSRVF GSNSGPIAEK YSVTTQLVMG
     GLTGWCAGYL FQRVGKIAAT AVGGGFLLLQ IANHSGYVQV DWKKVEKDVN KAKKRLKKKA
     NKAVPEINTL IEEATDFIKK NIVLSGGFVG GFLLGLAS