ID   FUND1_XENTR             Reviewed;         151 AA.
AC   B1H3B1; F6PSK0;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=FUN14 domain-containing protein 1;
GN   Name=fundc1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as an activator of hypoxia-induced mitophagy, an
CC       important mechanism for mitochondrial quality control. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FUN14 family. {ECO:0000305}.
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DR   EMBL; AAMC01015774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC161330; AAI61330.1; -; mRNA.
DR   RefSeq; NP_001120476.1; NM_001127004.1.
DR   AlphaFoldDB; B1H3B1; -.
DR   PaxDb; B1H3B1; -.
DR   GeneID; 100145592; -.
DR   KEGG; xtr:100145592; -.
DR   CTD; 139341; -.
DR   Xenbase; XB-GENE-964323; fundc1.
DR   eggNOG; KOG4099; Eukaryota.
DR   HOGENOM; CLU_095425_2_0_1; -.
DR   InParanoid; B1H3B1; -.
DR   OrthoDB; 1431148at2759; -.
DR   PhylomeDB; B1H3B1; -.
DR   Reactome; R-XTR-8934903; Receptor Mediated Mitophagy.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0031307; C:integral component of mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0000422; P:autophagy of mitochondrion; ISS:UniProtKB.
DR   GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
DR   InterPro; IPR007014; FUN14.
DR   PANTHER; PTHR21346; PTHR21346; 1.
DR   Pfam; PF04930; FUN14; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..151
FT                   /note="FUN14 domain-containing protein 1"
FT                   /id="PRO_0000416278"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           14..17
FT                   /note="YXXL"
SQ   SEQUENCE   151 AA;  16675 MW;  2556565CEC147D14 CRC64;
     MAARREPSSD DESYEVLDLT EYARRHHWWN RLFGRNSGPL TEKYSVATQI VMGGVSGWCA
     GFLFQKVGKL AATAVGGGFL LLQIASHGGY IQIDWKRVEK DVNKAKRKIK KEANKSVPEI
     NTLIEESTDF IKKNIVVSGG FVGGFLLGLA S