FUND2_HUMAN
ID FUND2_HUMAN Reviewed; 189 AA.
AC Q9BWH2; B2R7W5; D3DWY5; Q8NHX8; Q9H2I6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=FUN14 domain-containing protein 2 {ECO:0000305};
DE AltName: Full=Cervical cancer proto-oncogene 3 protein;
DE Short=HCC-3;
DE AltName: Full=Hepatitis C virus core-binding protein 6;
GN Name=FUNDC2 {ECO:0000312|HGNC:HGNC:24925}; Synonyms=HCBP6;
GN ORFNames=DC44, HCC3, PD03104;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12665903;
RA Li K., Wang L., Cheng J., Zhang L., Duan H., Lu Y., Yang J., Liu Y.,
RA Xia X., Wang G., Dong J., Li L., Zhong Y., Hong Y., Chen J.;
RT "Screening and cloning gene of hepatocyte protein interacting with
RT hepatitis C virus core protein.";
RL Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 16:351-353(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Dendritic cell;
RA Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.;
RT "A novel gene from human dendritic cells.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal muscle;
RA Frigimelica E., Lanfranchi G.;
RT "Study of 100 skeletal muscle full length mRNA (Telethon project B41).";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kim J.W.;
RT "Identification of a new oncogene in human cancers.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Eye, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND SER-151, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53 AND SER-151, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [13]
RP FUNCTION.
RX PubMed=25855506; DOI=10.1002/jcb.25188;
RA Gao L.L., Li M., Wang Q., Liu S.A., Zhang J.Q., Cheng J.;
RT "HCBP6 Modulates Triglyceride Homeostasis in Hepatocytes Via the
RT SREBP1c/FASN Pathway.";
RL J. Cell. Biochem. 116:2375-2384(2015).
RN [14]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=29187281; DOI=10.5483/bmbrep.2018.51.1.184;
RA Yang X., Han M., Liu S., Yuan X., Liu X., Feng S., Zhou L., Li Y., Lu H.,
RA Cheng J., Lin S.;
RT "HCBP6 upregulates human SREBP1c expression by binding to C/EBPbeta-binding
RT site in the SREBP1c promoter.";
RL BMB Rep. 51:33-38(2018).
RN [15]
RP TISSUE SPECIFICITY.
RX PubMed=30576423; DOI=10.1093/cvr/cvy311;
RA Ma Q., Zhang W., Zhu C., Liu J., Chen Q.;
RT "FUNDC2 regulates platelet activation through AKT/GSK-3beta/cGMP axis.";
RL Cardiovasc. Res. 115:1672-1679(2019).
RN [16]
RP SUBCELLULAR LOCATION, TOPOLOGY, AND FUNCTION.
RX PubMed=29786068; DOI=10.1038/s41418-018-0121-8;
RA Ma Q., Zhu C., Zhang W., Ta N., Zhang R., Liu L., Feng D., Cheng H.,
RA Liu J., Chen Q.;
RT "Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via
RT AKT signaling pathway.";
RL Cell Death Differ. 26:321-331(2019).
CC -!- FUNCTION: Binds directly and specifically 1,2-Diacyl-sn-glycero-3-
CC phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the
CC recruitment of PIP3 to mitochondria and may play a role in the
CC regulation of the platelet activation via AKT/GSK3B/cGMP signaling
CC pathways (PubMed:29786068). May act as transcription factor that
CC regulates SREBP1 (isoform SREBP-1C) expression in order to modulate
CC triglyceride (TG) homeostasis in hepatocytes (PubMed:29187281,
CC PubMed:25855506). {ECO:0000269|PubMed:25855506,
CC ECO:0000269|PubMed:29187281, ECO:0000269|PubMed:29786068}.
CC -!- INTERACTION:
CC Q9BWH2; Q13520: AQP6; NbExp=3; IntAct=EBI-714482, EBI-13059134;
CC Q9BWH2; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-714482, EBI-11343438;
CC Q9BWH2; P11912: CD79A; NbExp=3; IntAct=EBI-714482, EBI-7797864;
CC Q9BWH2; Q9UHD4: CIDEB; NbExp=3; IntAct=EBI-714482, EBI-7062247;
CC Q9BWH2; Q5RI15: COX20; NbExp=3; IntAct=EBI-714482, EBI-2834035;
CC Q9BWH2; Q9BUF7-2: CRB3; NbExp=3; IntAct=EBI-714482, EBI-17233035;
CC Q9BWH2; P00387: CYB5R3; NbExp=3; IntAct=EBI-714482, EBI-1046040;
CC Q9BWH2; Q15125: EBP; NbExp=3; IntAct=EBI-714482, EBI-3915253;
CC Q9BWH2; P34910-2: EVI2B; NbExp=3; IntAct=EBI-714482, EBI-17640610;
CC Q9BWH2; Q92915-2: FGF14; NbExp=3; IntAct=EBI-714482, EBI-12836320;
CC Q9BWH2; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-714482, EBI-13345167;
CC Q9BWH2; P48051: KCNJ6; NbExp=3; IntAct=EBI-714482, EBI-12017638;
CC Q9BWH2; P43628: KIR2DL3; NbExp=3; IntAct=EBI-714482, EBI-8632435;
CC Q9BWH2; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-714482, EBI-373355;
CC Q9BWH2; O14880: MGST3; NbExp=3; IntAct=EBI-714482, EBI-724754;
CC Q9BWH2; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-714482, EBI-7545592;
CC Q9BWH2; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-714482, EBI-10192441;
CC Q9BWH2; Q8N3Y7: SDR16C5; NbExp=3; IntAct=EBI-714482, EBI-3923480;
CC Q9BWH2; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-714482, EBI-18159983;
CC Q9BWH2; Q8TF71: SLC16A10; NbExp=3; IntAct=EBI-714482, EBI-17858931;
CC Q9BWH2; Q8N2U9: SLC66A2; NbExp=3; IntAct=EBI-714482, EBI-3907610;
CC Q9BWH2; P27105: STOM; NbExp=3; IntAct=EBI-714482, EBI-1211440;
CC Q9BWH2; Q8N9I0: SYT2; NbExp=3; IntAct=EBI-714482, EBI-8032987;
CC Q9BWH2; Q6P9G4: TMEM154; NbExp=3; IntAct=EBI-714482, EBI-13329239;
CC Q9BWH2; Q9Y320: TMX2; NbExp=3; IntAct=EBI-714482, EBI-6447886;
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000269|PubMed:29786068}; Multi-pass membrane protein
CC {ECO:0000255}. Nucleus {ECO:0000305|PubMed:29187281}.
CC -!- TISSUE SPECIFICITY: Highly expressed in platelets (at protein level).
CC {ECO:0000269|PubMed:30576423}.
CC -!- SIMILARITY: Belongs to the FUN14 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG44731.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY032594; AAK51136.1; -; mRNA.
DR EMBL; AF267862; AAG44731.1; ALT_FRAME; mRNA.
DR EMBL; AJ272054; CAC81242.1; -; mRNA.
DR EMBL; AF320778; AAN51931.1; -; mRNA.
DR EMBL; AK313143; BAG35962.1; -; mRNA.
DR EMBL; BX470111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471172; EAW72643.1; -; Genomic_DNA.
DR EMBL; CH471172; EAW72644.1; -; Genomic_DNA.
DR EMBL; BC000255; AAH00255.2; -; mRNA.
DR EMBL; BC072685; AAH72685.1; -; mRNA.
DR EMBL; BC108657; AAI08658.1; -; mRNA.
DR CCDS; CCDS14763.1; -.
DR RefSeq; NP_076423.2; NM_023934.3.
DR AlphaFoldDB; Q9BWH2; -.
DR BioGRID; 122440; 103.
DR IntAct; Q9BWH2; 59.
DR MINT; Q9BWH2; -.
DR STRING; 9606.ENSP00000358510; -.
DR GlyGen; Q9BWH2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BWH2; -.
DR PhosphoSitePlus; Q9BWH2; -.
DR SwissPalm; Q9BWH2; -.
DR BioMuta; FUNDC2; -.
DR DMDM; 74752400; -.
DR EPD; Q9BWH2; -.
DR jPOST; Q9BWH2; -.
DR MassIVE; Q9BWH2; -.
DR MaxQB; Q9BWH2; -.
DR PaxDb; Q9BWH2; -.
DR PeptideAtlas; Q9BWH2; -.
DR PRIDE; Q9BWH2; -.
DR ProteomicsDB; 79278; -.
DR Antibodypedia; 31390; 92 antibodies from 17 providers.
DR DNASU; 65991; -.
DR Ensembl; ENST00000369498.8; ENSP00000358510.3; ENSG00000165775.18.
DR GeneID; 65991; -.
DR KEGG; hsa:65991; -.
DR MANE-Select; ENST00000369498.8; ENSP00000358510.3; NM_023934.4; NP_076423.2.
DR UCSC; uc004fmw.4; human.
DR CTD; 65991; -.
DR DisGeNET; 65991; -.
DR GeneCards; FUNDC2; -.
DR HGNC; HGNC:24925; FUNDC2.
DR HPA; ENSG00000165775; Tissue enhanced (skeletal muscle, tongue).
DR MalaCards; FUNDC2; -.
DR MIM; 301042; gene.
DR neXtProt; NX_Q9BWH2; -.
DR OpenTargets; ENSG00000165775; -.
DR PharmGKB; PA134908797; -.
DR VEuPathDB; HostDB:ENSG00000165775; -.
DR eggNOG; KOG4099; Eukaryota.
DR GeneTree; ENSGT00940000154783; -.
DR HOGENOM; CLU_095425_2_0_1; -.
DR InParanoid; Q9BWH2; -.
DR OMA; TERYSMA; -.
DR OrthoDB; 1431148at2759; -.
DR PhylomeDB; Q9BWH2; -.
DR TreeFam; TF300280; -.
DR PathwayCommons; Q9BWH2; -.
DR SignaLink; Q9BWH2; -.
DR BioGRID-ORCS; 65991; 15 hits in 702 CRISPR screens.
DR ChiTaRS; FUNDC2; human.
DR GeneWiki; FUNDC2; -.
DR GenomeRNAi; 65991; -.
DR Pharos; Q9BWH2; Tbio.
DR PRO; PR:Q9BWH2; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9BWH2; protein.
DR Bgee; ENSG00000165775; Expressed in apex of heart and 125 other tissues.
DR ExpressionAtlas; Q9BWH2; baseline and differential.
DR Genevisible; Q9BWH2; HS.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:LIFEdb.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.
DR GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR GO; GO:0035356; P:cellular triglyceride homeostasis; IMP:UniProtKB.
DR GO; GO:0010543; P:regulation of platelet activation; ISS:UniProtKB.
DR InterPro; IPR007014; FUN14.
DR PANTHER; PTHR21346; PTHR21346; 1.
DR Pfam; PF04930; FUN14; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Transmembrane; Transmembrane helix.
FT CHAIN 1..189
FT /note="FUN14 domain-containing protein 2"
FT /id="PRO_0000314615"
FT TOPO_DOM 1..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:29786068"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..107
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305|PubMed:29786068"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:29786068"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..189
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305|PubMed:29786068"
FT MOD_RES 10
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 53
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 151
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
SQ SEQUENCE 189 AA; 20676 MW; 425CC27F23E240D9 CRC64;
METSAPRAGS QVVATTARHS AAYRADPLRV SSRDKLTEMA ASSQGNFEGN FESLDLAEFA
KKQPWWRKLF GQESGPSAEK YSVATQLFIG GVTGWCTGFI FQKVGKLAAT AVGGGFFLLQ
LANHTGYIKV DWQRVEKDMK KAKEQLKIRK SNQIPTEVRS KAEEVVSFVK KNVLVTGGFF
GGFLLGMAS
