FUR1_MYCFO
ID FUR1_MYCFO Reviewed; 161 AA.
AC O69450;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Ferric uptake regulation protein 1;
DE Short=Ferric uptake regulator 1;
DE Flags: Fragment;
GN Name=fur1; Synonyms=furA I;
OS Mycolicibacterium fortuitum (Mycobacterium fortuitum).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1766;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 6841 / DSM 46621 / CIP 104534 / JCM 6387 / KCTC 9510 / NBRC
RC 13159 / NCTC 10394;
RA Menendez M.C.;
RL Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a global negative controlling element, employing
CC Fe(2+) as a cofactor to bind the operator of the repressed genes.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Fur family. {ECO:0000305}.
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DR EMBL; Y17061; CAA76608.1; -; Genomic_DNA.
DR STRING; 1766.XA26_32260; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07153; Fur_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.1490.190; -; 1.
DR InterPro; IPR002481; FUR.
DR InterPro; IPR043135; Fur_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33202; PTHR33202; 1.
DR Pfam; PF01475; FUR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Iron; Metal-binding; Repressor; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..>161
FT /note="Ferric uptake regulation protein 1"
FT /id="PRO_0000095560"
FT BINDING 94
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 97
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT NON_TER 161
SQ SEQUENCE 161 AA; 17456 MW; 658A64BD1154FEEE CRC64;
MADGLDFTGM LRSAGLRITR PRLAVLNAVK EHPHAETDHV IRAVRVQLPD VSHQTVYDXL
NALTAAGLVR RIQPTGSVAR YETRVNDNHH HVVCRSCGAI ADVDCAVGDA PCLTAADDNG
FDIDEAEVIY WASALTARDL RVLDDSPVAH QMKGKAMPPN T