FUR4_SCHPO
ID FUR4_SCHPO Reviewed; 581 AA.
AC Q10279; Q9HE14;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 14-AUG-2001, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Uracil permease;
GN Name=fur4; ORFNames=SPAC1399.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9730284;
RX DOI=10.1002/(sici)1097-0061(199808)14:11<1051::aid-yea287>3.0.co;2-1;
RA de Montigny J., Straub M.L., Wagner R., Bach M.L., Chevallier M.R.;
RT "The uracil permease of Schizosaccharomyces pombe: a representative of a
RT family of 10 transmembrane helix transporter proteins of yeasts.";
RL Yeast 14:1051-1059(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-572, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Transport of uracil.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000305}.
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DR EMBL; X98696; CAA67256.1; -; Genomic_DNA.
DR EMBL; CU329670; CAC19744.1; -; Genomic_DNA.
DR PIR; T43295; T43295.
DR RefSeq; NP_593511.1; NM_001018945.2.
DR AlphaFoldDB; Q10279; -.
DR BioGRID; 279041; 2.
DR STRING; 4896.SPAC1399.03.1; -.
DR TCDB; 2.A.39.3.7; the nucleobase:cation symporter-1 (ncs1) family.
DR iPTMnet; Q10279; -.
DR MaxQB; Q10279; -.
DR PaxDb; Q10279; -.
DR PRIDE; Q10279; -.
DR EnsemblFungi; SPAC1399.03.1; SPAC1399.03.1:pep; SPAC1399.03.
DR GeneID; 2542586; -.
DR KEGG; spo:SPAC1399.03; -.
DR PomBase; SPAC1399.03; fur4.
DR VEuPathDB; FungiDB:SPAC1399.03; -.
DR eggNOG; KOG2466; Eukaryota.
DR HOGENOM; CLU_021555_2_0_1; -.
DR InParanoid; Q10279; -.
DR OMA; CGTDMSA; -.
DR PhylomeDB; Q10279; -.
DR PRO; PR:Q10279; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:PomBase.
DR GO; GO:0000324; C:fungal-type vacuole; IDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0000139; C:Golgi membrane; IDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:PomBase.
DR GO; GO:0044853; C:plasma membrane raft; ISO:PomBase.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015210; F:uracil transmembrane transporter activity; IMP:PomBase.
DR GO; GO:0015505; F:uracil:cation symporter activity; ISO:PomBase.
DR GO; GO:0015851; P:nucleobase transport; IBA:GO_Central.
DR GO; GO:0098721; P:uracil import across plasma membrane; IMP:PomBase.
DR InterPro; IPR012681; NCS1.
DR InterPro; IPR001248; Pur-cyt_permease.
DR InterPro; IPR045225; Uracil/uridine/allantoin_perm.
DR PANTHER; PTHR30618; PTHR30618; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
DR TIGRFAMs; TIGR00800; ncs1; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..581
FT /note="Uracil permease"
FT /id="PRO_0000197924"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 496..516
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 572
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT CONFLICT 573..581
FT /note="SKKLSGCFP -> RQKIIGLFSLGKLLFVV (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 581 AA; 64177 MW; DFBE6F7C5602438F CRC64;
MESVDNNSFF SRIRNSNAYR KVKDFVILDH RPGMTMAERM LTNKDLYPVP PSKRLWGPWN
FISFWLADAV NINTWMISAT AIELGLNWWE AWICVWVGYL ICGILVATTG RPGAVYHISF
PVLSRSSFGT WGSLWPILNR SVLACVWYGV QAWIGGECVV LMIRSIWPSF SHIPNTMAKS
GTETYQWVGF FIFWLLSNIA IWFPVHQIRH LFTFKAIVAP PAAIAFLIWA LVKAHGAGPV
IHEPTKLGQY EHAWVVINGI VTCIDGFATL IVNNPDFARF ATTPGAVHWP QIITVPLAFG
VTSLIGVLVS SASKAIYGTT LWDPTQLLAS FLDHSNAHGV RAGVFFIAFG LCIAQLGVNI
AANSVSAGND LSALLPTVIN VRRGGYIASI IALCMCPWNL LSSNNNFTTY LSSYSVFLSS
FAGVIIADYY FVRKGLIRVA PLYSSSSSSP YYFWKGINFR AFASYICGML INIVGMAGST
GQKVPKVANT MFNLNYFLGI TVACLSHIII CKIFPVTECG EKMLSEVPEE ADDYLLTLAS
EDSIDKDSTS EIYIDGLPTE KEVEKDDVLS ITSKKLSGCF P
