ID   FUR_PSEPU               Reviewed;         134 AA.
AC   Q52083;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Ferric uptake regulation protein;
DE            Short=Ferric uptake regulator;
GN   Name=fur;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WCS358;
RX   PubMed=7623664; DOI=10.1111/j.1365-2958.1995.tb02283.x;
RA   Venturi V., Ottevanger C., Bracke M., Weisbeek P.J.;
RT   "Iron regulation of siderophore biosynthesis and transport in Pseudomonas
RT   putida WCS358: involvement of a transcriptional activator and of the Fur
RT   protein.";
RL   Mol. Microbiol. 15:1081-1093(1995).
CC   -!- FUNCTION: Fur acts as a repressor, employing Fe(2+) as a cofactor to
CC       bind the operator of the iron transport operon. Involved in the
CC       siderophore pseudobactin 358 biosynthesis regulation.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Fur family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X82037; CAA57557.1; -; Genomic_DNA.
DR   PIR; S61844; S61844.
DR   AlphaFoldDB; Q52083; -.
DR   SMR; Q52083; -.
DR   STRING; 1240350.AMZE01000021_gene1522; -.
DR   eggNOG; COG0735; Bacteria.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd07153; Fur_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.1490.190; -; 1.
DR   InterPro; IPR002481; FUR.
DR   InterPro; IPR043135; Fur_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33202; PTHR33202; 1.
DR   Pfam; PF01475; FUR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Iron; Metal-binding; Repressor; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..134
FT                   /note="Ferric uptake regulation protein"
FT                   /id="PRO_0000095569"
FT   REGION          1..83
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          84..134
FT                   /note="Dimerization"
FT                   /evidence="ECO:0000250"
FT   BINDING         32
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         80
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         86
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         88
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         89
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         100
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         107
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         124
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   134 AA;  15181 MW;  357507EEF3B5B136 CRC64;
     MVENSELRKA GLKVTLPRVK ILQMLDSTEQ RHMSAEECIK ALMEAGEDVG LATVYRVLTQ
     FEAAGLVVRH NFDGGHAVFE LADGGHHDHM VNVETSEVIE FMDAEIEKRQ REIVAEHGFE
     LVDHNLVLYV RKKK