FUR_RHILV
ID FUR_RHILV Reviewed; 142 AA.
AC O07315;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 17-JAN-2003, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Ferric uptake regulation protein;
DE Short=Ferric uptake regulator;
GN Name=fur;
OS Rhizobium leguminosarum bv. viciae.
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX NCBI_TaxID=387;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=8401:PRL1;
RX PubMed=9835040; DOI=10.1111/j.1574-6968.1998.tb13286.x;
RA de Luca N.G., Wexler M., Pereira M.J., Yeoman K.H., Johnston A.W.;
RT "Is the fur gene of Rhizobium leguminosarum essential?";
RL FEMS Microbiol. Lett. 168:289-295(1998).
RN [2]
RP SEQUENCE REVISION TO 80.
RA Wexler M.;
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a global negative controlling element, employing
CC Fe(2+) as a cofactor to bind the operator of the repressed genes.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Fur family. {ECO:0000305}.
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DR EMBL; Y13657; CAA74010.2; -; Genomic_DNA.
DR RefSeq; WP_003544875.1; NZ_WIFD01000001.1.
DR PDB; 5FD5; X-ray; 1.91 A; A/B/C/D/E=2-142.
DR PDB; 5FD6; X-ray; 2.48 A; A/B/C/D=1-142.
DR PDBsum; 5FD5; -.
DR PDBsum; 5FD6; -.
DR AlphaFoldDB; O07315; -.
DR SMR; O07315; -.
DR GeneID; 61421945; -.
DR GeneID; 67485974; -.
DR OMA; YLYGVCT; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07153; Fur_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.1490.190; -; 1.
DR InterPro; IPR002481; FUR.
DR InterPro; IPR043135; Fur_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33202; PTHR33202; 1.
DR Pfam; PF01475; FUR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; DNA-binding; Iron; Metal-binding; Repressor;
KW Transcription; Transcription regulation; Zinc.
FT CHAIN 1..142
FT /note="Ferric uptake regulation protein"
FT /id="PRO_0000095570"
FT REGION 1..87
FT /note="DNA-binding"
FT /evidence="ECO:0000250"
FT REGION 88..142
FT /note="Dimerization"
FT /evidence="ECO:0000250"
FT BINDING 36
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 84
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 90
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 92
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 104
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 111
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 128
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT HELIX 8..14
FT /evidence="ECO:0007829|PDB:5FD5"
FT HELIX 21..32
FT /evidence="ECO:0007829|PDB:5FD5"
FT HELIX 39..49
FT /evidence="ECO:0007829|PDB:5FD5"
FT HELIX 55..67
FT /evidence="ECO:0007829|PDB:5FD5"
FT STRAND 70..75
FT /evidence="ECO:0007829|PDB:5FD5"
FT TURN 77..79
FT /evidence="ECO:0007829|PDB:5FD6"
FT STRAND 81..85
FT /evidence="ECO:0007829|PDB:5FD5"
FT STRAND 92..96
FT /evidence="ECO:0007829|PDB:5FD5"
FT TURN 97..99
FT /evidence="ECO:0007829|PDB:5FD5"
FT STRAND 102..105
FT /evidence="ECO:0007829|PDB:5FD5"
FT HELIX 108..120
FT /evidence="ECO:0007829|PDB:5FD5"
FT STRAND 123..136
FT /evidence="ECO:0007829|PDB:5FD5"
SQ SEQUENCE 142 AA; 16713 MW; AF7914790B97911B CRC64;
MTDVAKTLEE LCTERGMRMT EQRRVIARIL EDSEDHPDVE ELYRRSVKVD AKISISTVYR
TVKLFEDAGI IARHDFRDGR SRYETVPEEH HDHLIDLKTG TVIEFRSPEI EALQERIARE
HGFRLVDHRL ELYGVPLKKE DL
