ID   FUR_SYNE7               Reviewed;         147 AA.
AC   Q55244; Q31PK2;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Ferric uptake regulation protein;
DE            Short=Ferric uptake regulator;
GN   Name=fur; OrderedLocusNames=Synpcc7942_0987;
OS   Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans
OS   R2).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=1140;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8704986; DOI=10.1099/13500872-142-6-1469;
RA   Ghassemian M., Straus N.A.;
RT   "Fur regulates the expression of iron-stress genes in the cyanobacterium
RT   Synechococcus sp. strain PCC 7942.";
RL   Microbiology 142:1469-1476(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7942 / FACHB-805;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a global negative controlling element, employing
CC       Fe(2+) as a cofactor to bind the operator of the repressed genes.
CC       Regulates genes involved in iron scavenging or photosynthetic electron
CC       transport.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Fur family. {ECO:0000305}.
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DR   EMBL; L41065; AAB41546.1; -; Genomic_DNA.
DR   EMBL; CP000100; ABB57017.1; -; Genomic_DNA.
DR   RefSeq; WP_011242869.1; NC_007604.1.
DR   AlphaFoldDB; Q55244; -.
DR   SMR; Q55244; -.
DR   STRING; 1140.Synpcc7942_0987; -.
DR   PRIDE; Q55244; -.
DR   EnsemblBacteria; ABB57017; ABB57017; Synpcc7942_0987.
DR   KEGG; syf:Synpcc7942_0987; -.
DR   eggNOG; COG0735; Bacteria.
DR   HOGENOM; CLU_096072_3_1_3; -.
DR   OMA; HDHVILT; -.
DR   OrthoDB; 1630127at2; -.
DR   BioCyc; SYNEL:SYNPCC7942_0987-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd07153; Fur_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.1490.190; -; 1.
DR   InterPro; IPR002481; FUR.
DR   InterPro; IPR043135; Fur_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33202; PTHR33202; 1.
DR   Pfam; PF01475; FUR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Iron; Metal-binding; Repressor; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..147
FT                   /note="Ferric uptake regulation protein"
FT                   /id="PRO_0000095582"
FT   REGION          1..90
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          91..147
FT                   /note="Dimerization"
FT                   /evidence="ECO:0000250"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         86
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         93
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         95
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         96
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         99
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         102
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         107
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        66..85
FT                   /note="Missing (in Ref. 1; AAB41546)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   147 AA;  16845 MW;  E31E043413AC99CB CRC64;
     MTYTAASLKA ELNERGWRLT PQREEILRVF QNLPAGEHLS AEDLYNHLLS RNSPISLSTI
     YRTLKLMARM GLLRELDLAE DHKHYELNQP LKHHHHLICV SCSKTIEFKS DSVLKIGAKT
     SEKEGYHLLD CQLTIHGVCP TCQRSLV