FUR_VIBA7
ID FUR_VIBA7 Reviewed; 149 AA.
AC P37736; F7YNE5; Q56579;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Ferric uptake regulation protein;
DE Short=Ferric uptake regulator;
GN Name=fur; OrderedLocusNames=VAA_03429;
OS Vibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=882102;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 68554 / 775;
RX PubMed=8282699; DOI=10.1128/jb.176.1.213-220.1994;
RA Tolmasky M.E., Wertheimer A.M., Actis L.A., Crosa J.H.;
RT "Characterization of the Vibrio anguillarum fur gene: role in regulation of
RT expression of the FatA outer membrane protein and catechols.";
RL J. Bacteriol. 176:213-220(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 68554 / 775 / 775 NR, and ATCC 68554 / 775 / 775met9;
RA Wertheimer A.M., Tolmasky M.E., Actis L.A., Crosa J.H.;
RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 68554 / 775;
RX PubMed=21576332; DOI=10.1128/iai.05138-11;
RA Naka H., Dias G.M., Thompson C.C., Dubay C., Thompson F.L., Crosa J.H.;
RT "Complete genome sequence of the marine fish pathogen Vibrio anguillarum
RT harboring the pJM1 virulence plasmid and genomic comparison with other
RT virulent strains of V. anguillarum and V. ordalii.";
RL Infect. Immun. 79:2889-2900(2011).
CC -!- FUNCTION: Fur acts as a repressor, employing Fe(2+) as a cofactor to
CC bind the operator of the iron transport operon. It plays a role in the
CC regulation of expression of the outer membrane protein fatA and
CC synthesis of catechols which are intermediates in the biosynthesis of
CC anguibactin.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Fur family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AEH32644.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; L19717; AAA16861.1; -; Unassigned_DNA.
DR EMBL; L33344; AAA27522.1; -; Genomic_DNA.
DR EMBL; L33342; AAA27520.1; -; Genomic_DNA.
DR EMBL; CP002284; AEH32644.1; ALT_INIT; Genomic_DNA.
DR PIR; A36870; A36870.
DR RefSeq; WP_010318689.1; NC_015633.1.
DR AlphaFoldDB; P37736; -.
DR SMR; P37736; -.
DR EnsemblBacteria; AEH32644; AEH32644; VAA_03429.
DR GeneID; 63946437; -.
DR KEGG; van:VAA_03429; -.
DR eggNOG; COG0735; Bacteria.
DR HOGENOM; CLU_096072_3_3_6; -.
DR Proteomes; UP000006800; Chromosome I.
DR CollecTF; EXPREG_00000a70; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEP:CollecTF.
DR CDD; cd07153; Fur_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.1490.190; -; 1.
DR InterPro; IPR002481; FUR.
DR InterPro; IPR043135; Fur_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33202; PTHR33202; 1.
DR Pfam; PF01475; FUR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Iron; Metal-binding; Repressor; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..149
FT /note="Ferric uptake regulation protein"
FT /id="PRO_0000095584"
FT REGION 1..84
FT /note="DNA-binding"
FT /evidence="ECO:0000250"
FT REGION 85..142
FT /note="Dimerization"
FT /evidence="ECO:0000250"
FT BINDING 33
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 81
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 87
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 89
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 90
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 96
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 101
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 108
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 125
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT VARIANT 104
FT /note="D -> G (in strain: 775met9)"
FT MUTAGEN 77
FT /note="K->G: Impaired regulatory activity."
SQ SEQUENCE 149 AA; 16970 MW; 07DDD0A4A85CA72F CRC64;
MSDNNQALKD AGLKVTLPRL KILEVLQQPE CQHISAEELY KKLIDLGEEI GLATVYRVLN
QFDDAGIVTR HHFEGGKSVF ELSTQHHHDH LVCLDCGEVI EFSDEVIEQR QREIAEQYNV
QLTNHSLYLY GKCADGSCKQ NPNAHKSKR
