ID   FUS3_GIBM7              Reviewed;         220 AA.
AC   W7MMJ0;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Glutathione S-transferase-like protein FUS3 {ECO:0000305};
DE            EC=2.5.1.- {ECO:0000305};
DE   AltName: Full=Fusarin biosynthesis protein 3 {ECO:0000303|PubMed:22652150};
GN   Name=FUS3 {ECO:0000303|PubMed:22652150}; ORFNames=FVEG_11084;
OS   Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS   fungus) (Fusarium verticillioides).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=334819;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M3125 / FGSC 7600;
RX   PubMed=20237561; DOI=10.1038/nature08850;
RA   Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA   Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA   Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA   Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA   Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA   Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA   Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA   Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA   Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA   Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA   Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA   Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT   "Comparative genomics reveals mobile pathogenicity chromosomes in
RT   Fusarium.";
RL   Nature 464:367-373(2010).
RN   [2]
RP   FUNCTION.
RX   PubMed=22652150; DOI=10.1016/j.fgb.2012.05.010;
RA   Brown D.W., Butchko R.A., Busman M., Proctor R.H.;
RT   "Identification of gene clusters associated with fusaric acid, fusarin, and
RT   perithecial pigment production in Fusarium verticillioides.";
RL   Fungal Genet. Biol. 49:521-532(2012).
CC   -!- FUNCTION: Glutathione S-transferase-like protein; part of the gene
CC       cluster that mediates the biosynthesis of the mycotoxin fusarin C
CC       (PubMed:22652150). Within the cluster, FUS1, FUS2, FUS8 and FUS9 are
CC       sufficient for fusarin production (By similarity). The other FUS
CC       cluster members are not essential for fusarin C biosynthesis (By
CC       similarity). {ECO:0000250|UniProtKB:S0EHD0,
CC       ECO:0000269|PubMed:22652150}.
CC   -!- SIMILARITY: Belongs to the GST superfamily. {ECO:0000305}.
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DR   EMBL; DS022257; EWG52306.1; -; Genomic_DNA.
DR   RefSeq; XP_018758497.1; XM_018900247.1.
DR   AlphaFoldDB; W7MMJ0; -.
DR   SMR; W7MMJ0; -.
DR   STRING; 117187.FVEG_11084T0; -.
DR   EnsemblFungi; FVEG_11084T0; FVEG_11084T0; FVEG_11084.
DR   GeneID; 30068620; -.
DR   KEGG; fvr:FVEG_11084; -.
DR   VEuPathDB; FungiDB:FVEG_11084; -.
DR   eggNOG; KOG0867; Eukaryota.
DR   HOGENOM; CLU_011226_3_2_1; -.
DR   OMA; WICYAQG; -.
DR   OrthoDB; 1341490at2759; -.
DR   Proteomes; UP000009096; Chromosome 9.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase.
FT   CHAIN           1..220
FT                   /note="Glutathione S-transferase-like protein FUS3"
FT                   /id="PRO_0000437368"
FT   DOMAIN          3..84
FT                   /note="GST N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00684"
FT   DOMAIN          90..220
FT                   /note="GST C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00685"
SQ   SEQUENCE   220 AA;  24372 MW;  19A26ABA70A36BAD CRC64;
     MTSFGTLYTY MPNARVFKIL AAAKLNNLII EIPAYQHGVT NKSAEFLSKF PAGKVPAFEG
     PDGFCLVESD AIAQYVAQSG PQASQLLGQD AMSSAKIRQW ISFFAEEIYP TVLDLVMWRV
     GLGAFDETTE IKALAQLAYG LSVLEKHLNP GILLTGDELT LADLTGASTL LWAFMHIIDE
     PMRQQYPNVV AWYLKVVQNE EVKEVFGKPN LIEKRRIGAK