ID   FUS5_GIBM7              Reviewed;         233 AA.
AC   W7MWX7;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Esterase FUS5 {ECO:0000250|UniProtKB:Q0C8M2};
DE            EC=3.1.2.- {ECO:0000305};
DE   AltName: Full=Fusarin biosynthesis protein 5 {ECO:0000303|PubMed:22652150};
GN   Name=FUS5 {ECO:0000303|PubMed:22652150}; ORFNames=FVEG_11082;
OS   Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS   fungus) (Fusarium verticillioides).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=334819;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M3125 / FGSC 7600;
RX   PubMed=20237561; DOI=10.1038/nature08850;
RA   Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA   Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA   Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA   Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA   Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA   Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA   Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA   Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA   Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA   Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA   Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA   Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT   "Comparative genomics reveals mobile pathogenicity chromosomes in
RT   Fusarium.";
RL   Nature 464:367-373(2010).
RN   [2]
RP   FUNCTION.
RX   PubMed=22652150; DOI=10.1016/j.fgb.2012.05.010;
RA   Brown D.W., Butchko R.A., Busman M., Proctor R.H.;
RT   "Identification of gene clusters associated with fusaric acid, fusarin, and
RT   perithecial pigment production in Fusarium verticillioides.";
RL   Fungal Genet. Biol. 49:521-532(2012).
CC   -!- FUNCTION: Esterase; part of the gene cluster that mediates the
CC       biosynthesis of the mycotoxin fusarin C (PubMed:22652150). Within the
CC       cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin
CC       production (By similarity). The other FUS cluster members are not
CC       essential for fusarin C biosynthesis (By similarity).
CC       {ECO:0000250|UniProtKB:S0EES1, ECO:0000269|PubMed:22652150}.
CC   -!- SIMILARITY: Belongs to the LovG family. {ECO:0000305}.
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DR   EMBL; DS022257; EWG52304.1; -; Genomic_DNA.
DR   RefSeq; XP_018758495.1; XM_018900245.1.
DR   AlphaFoldDB; W7MWX7; -.
DR   SMR; W7MWX7; -.
DR   STRING; 334819.W7MWX7; -.
DR   EnsemblFungi; FVEG_11082T0; FVEG_11082T0; FVEG_11082.
DR   GeneID; 30068618; -.
DR   KEGG; fvr:FVEG_11082; -.
DR   VEuPathDB; FungiDB:FVEG_11082; -.
DR   eggNOG; KOG2551; Eukaryota.
DR   HOGENOM; CLU_051938_0_2_1; -.
DR   OMA; FFDGCGP; -.
DR   OrthoDB; 1190789at2759; -.
DR   Proteomes; UP000009096; Chromosome 9.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR005645; FSH_dom.
DR   Pfam; PF03959; FSH1; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..233
FT                   /note="Esterase FUS5"
FT                   /id="PRO_0000437370"
FT   ACT_SITE        105
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:P38777"
FT   ACT_SITE        159
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:P38777"
FT   ACT_SITE        187
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:P38777"
SQ   SEQUENCE   233 AA;  26019 MW;  8A3C211A31BBBFCA CRC64;
     MVHRPRLLCL HGGGASSQIM RIQFSKLESA LRKTFQLVFL EGPLDSAPGP GVLPFFKDFG
     PYSCWVSDDR SLSPEEKRQE ETNAIAYIKT FMLQYGPFAG ILGFSQGARA AASILLEQQR
     EAFTHDSLFG VFFCGTFPPF IPDAPDISLP TIHVLGLTDP YLRESEVLLE HCTQQSVRRV
     IKFNGGHHMP TSSDVTQQIA DVISMTYRTS QRKRVSGIWK KNVVDSRPSA LEI