ID   FUSC3_FUSCU             Reviewed;         450 AA.
AC   Q8J1X7;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Allergen Fus c 3;
DE   AltName: Allergen=Fus c 3;
OS   Fusarium culmorum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=5516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX   PubMed=12695122; DOI=10.1016/s0161-5890(03)00026-9;
RA   Hoff M., Ballmer-Weber B.K., Niggemann B., Cistero-Bahima A.,
RA   San Miguel-Moncin M., Conti A., Haustein D., Vieths S.;
RT   "Molecular cloning and immunological characterisation of potential
RT   allergens from the mould Fusarium culmorum.";
RL   Mol. Immunol. 39:965-975(2003).
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC       {ECO:0000269|PubMed:12695122}.
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DR   EMBL; AY167564; AAN73248.1; -; mRNA.
DR   AlphaFoldDB; Q8J1X7; -.
DR   Allergome; 1023; Fus c 3.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   1: Evidence at protein level;
KW   Allergen; DNA-binding.
FT   CHAIN           1..450
FT                   /note="Allergen Fus c 3"
FT                   /id="PRO_0000127182"
FT   DOMAIN          368..441
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          18..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          99..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          185..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..216
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..257
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..357
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..377
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   450 AA;  48938 MW;  3BF89C3760851938 CRC64;
     MAGDHAGDQS FYDFLIEEPE MIAPTPPGQF PHQQPISSPN RTSRNTPLRP ESTEIETHHH
     ANHPPALPVL GMQLPVPGTV PESSRAQSRA SLNLDIDLDL HAPSHPSHLS HGAPHEQEHA
     HEIQRHRAHS AQSSAGLPPT GFASHLPPAS SGPVSLGWNM YHVPPNLHLN ANQFNFEVPG
     HMNVSGHPTH LEHSSTNPNS FHYEHNIVSP SSIHPSTAHF DGEVPSQWDD SLGHGASTPK
     VRTPSHHVSS NPWAEINEPT GGDNDNLAPV TRPRKPARAR RQKKEPRKLS DASQGARSSS
     TGGTAHSVSD AASPSSTSHQ SRASLTSKSA SMTSAASTAS SRKSKLRSAS RTSKNTLDKP
     NDTAEDRRTR ASHNLVEKQY RNRLNAQFES LLHALPEQIR HGDNGGGNGN VDNESEQAND
     LDRRVSKGEV LEMARRHIEA LERERNQLGT