ID   FUSC_BURCE              Reviewed;         346 AA.
AC   P24128;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Fusaric acid resistance protein FusC;
GN   Name=fusC;
OS   Burkholderia cepacia (Pseudomonas cepacia).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=UK1;
RX   PubMed=1370369; DOI=10.1271/bbb1961.55.1913;
RA   Utsumi R., Yagi T., Katayama S., Katsuragi K., Tachibana K., Toyoda H.,
RA   Ouchi S., Obata K., Shibano Y., Noda M.;
RT   "Molecular cloning and characterization of the fusaric acid-resistance gene
RT   from Pseudomonas cepacia.";
RL   Agric. Biol. Chem. 55:1913-1918(1991).
CC   -!- FUNCTION: Involved in the resistance (detoxification) of the fungal
CC       toxin fusaric acid.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the aromatic acid exporter ArAE (TC 2.A.85)
CC       family. {ECO:0000305}.
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DR   EMBL; S77489; AAC60390.1; -; Genomic_DNA.
DR   EMBL; D12503; BAA02066.1; -; Genomic_DNA.
DR   PIR; JS0511; JS0511.
DR   AlphaFoldDB; P24128; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR006726; PHBA_efflux_AaeB/fusaric-R.
DR   Pfam; PF04632; FUSC; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..346
FT                   /note="Fusaric acid resistance protein FusC"
FT                   /id="PRO_0000210088"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   346 AA;  37870 MW;  6BCC53A01E24CE9E CRC64;
     MSAMTRVSEV IIGIVSAGVV SALVFPRYTG EQMRTTVRKR FGSFVDYVAS ALSGQLDRAH
     IETIHTRFAY VVGFEAARSM AVFEDPDTRM RSGRLARLNS EFMSASSRFH ALHQLMNRLH
     AAGAQAAIDA IEPYFREIAP LLTRNGEPVR TSIDAAHSAE QLLAWRDALP RRIRATRAEL
     ETQPDFPLLD FDTAAELLYR FITDLQEYAA TYASLATATH ERERWIERYE PRTNKTAATI
     AGIRTATVIL ALGWFWIETA WPSGVMLVLN AAATCALASS APRPTAMAAQ MGMGTALAVC
     TGFLLTFGIY PRIDGFVLLC AALAPLLAIG IYMSLKPKLA GYGGAI