FUS_BPPH6
ID FUS_BPPH6 Reviewed; 168 AA.
AC P11128;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Fusion protein P6;
GN Name=P6;
OS Pseudomonas phage phi6 (Bacteriophage phi-6).
OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Vidaverviricetes;
OC Mindivirales; Cystoviridae; Cystovirus.
OX NCBI_TaxID=10879;
OH NCBI_TaxID=319; Pseudomonas savastanoi pv. phaseolicola (Pseudomonas syringae pv. phaseolicola).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA], AND PROTEIN SEQUENCE OF 2-15.
RX PubMed=3347997; DOI=10.1016/0042-6822(88)90245-0;
RA Gottlieb P., Metzger S., Romantschuk M., Carton J., Strassman J.,
RA Bamford D.H., Kalkkinen N., Mindich L.;
RT "Nucleotide sequence of the middle dsRNA segment of bacteriophage phi 6:
RT placement of the genes of membrane-associated proteins.";
RL Virology 163:183-190(1988).
RN [2]
RP INTERACTION WITH P3.
RX PubMed=6868373; DOI=10.1016/0042-6822(83)90158-7;
RA Stitt B.L., Mindich L.;
RT "The structure of bacteriophage phi 6: protease digestion of phi 6
RT virions.";
RL Virology 127:459-462(1983).
RN [3]
RP FUNCTION.
RX PubMed=3608985; DOI=10.1002/j.1460-2075.1987.tb02388.x;
RA Bamford D.H., Romantschuk M., Somerharju P.J.;
RT "Membrane fusion in prokaryotes: bacteriophage phi 6 membrane fuses with
RT the Pseudomonas syringae outer membrane.";
RL EMBO J. 6:1467-1473(1987).
CC -!- FUNCTION: Mediates the fusion with the host outer membrane during virus
CC entry into the host cell. {ECO:0000269|PubMed:3608985}.
CC -!- SUBUNIT: Interacts with P3. {ECO:0000305|PubMed:6868373}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
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DR EMBL; M17462; AAA68484.1; -; Genomic_RNA.
DR PIR; B28648; P6BPF6.
DR RefSeq; NP_620350.1; NC_003716.1.
DR SMR; P11128; -.
DR GeneID; 956440; -.
DR KEGG; vg:956440; -.
DR Proteomes; UP000002610; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098997; P:fusion of virus membrane with host outer membrane; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Fusion of virus membrane with host membrane;
KW Fusion of virus membrane with host outer membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix;
KW Viral envelope protein; Viral penetration into host cytoplasm; Virion;
KW Virus entry into host cell.
FT INIT_MET 1
FT /note="Removed; by host"
FT /evidence="ECO:0000269|PubMed:3347997"
FT CHAIN 2..168
FT /note="Fusion protein P6"
FT /id="PRO_0000164640"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 168 AA; 17360 MW; 3D9ACD305FD238C8 CRC64;
MSIFSSLFKV IKKVISKVVA TLKKIFKKIW PLLLIVAIIY FAPYLAGFFT SAGFTGIGGI
FSSIATTITP TLTSFLSTAW SGVGSLASTA WSGFQSLGMG TQLAVVSGAA ALIAPEETAQ
LVTEIGTTVG DIAGTIIGGV AKALPGWIWI AAGGLAVWAL WPSSDSKE
