ID   FUS_NPVCF               Reviewed;         509 AA.
AC   P41717;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Major envelope glycoprotein;
DE   AltName: Full=gp67;
DE   Flags: Precursor;
GN   Name=GP67; Synonyms=P67;
OS   Choristoneura fumiferana nuclear polyhedrosis virus (CfMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=208973;
OH   NCBI_TaxID=7141; Choristoneura fumiferana (Spruce budworm moth) (Archips fumiferana).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Ireland;
RX   PubMed=8021612; DOI=10.1099/0022-1317-75-7-1811;
RA   Hill J.E., Faulkner P.;
RT   "Identification of the gp67 gene of a baculovirus pathogenic to the spruce
RT   budworm, Choristoneura fumiferana multinucleocapsid nuclear polyhedrosis
RT   virus.";
RL   J. Gen. Virol. 75:1811-1813(1994).
CC   -!- FUNCTION: Envelope phosphoglycoprotein which mediates the fusion of
CC       viral and host endosomal membranes leading to virus entry into the host
CC       cell. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}. Host cell membrane {ECO:0000305};
CC       Single-pass membrane protein {ECO:0000305}.
CC   -!- PTM: Palmitoylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the baculoviridae gp64 family. {ECO:0000305}.
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DR   EMBL; L12412; AAA67522.1; -; Genomic_DNA.
DR   RefSeq; NP_848430.1; NC_004778.3.
DR   SMR; P41717; -.
DR   GeneID; 1482739; -.
DR   KEGG; vg:1482739; -.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019048; P:modulation by virus of host process; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR004955; Baculovirus_Gp64.
DR   Pfam; PF03273; Baculo_gp64; 1.
PE   3: Inferred from homology;
KW   Fusion of virus membrane with host endosomal membrane;
KW   Fusion of virus membrane with host membrane; Glycoprotein;
KW   Host cell membrane; Host membrane; Lipoprotein; Membrane; Palmitate;
KW   Phosphoprotein; Signal; Transmembrane; Transmembrane helix;
KW   Viral envelope protein; Viral penetration into host cytoplasm; Virion;
KW   Virus entry into host cell.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..509
FT                   /note="Major envelope glycoprotein"
FT                   /id="PRO_0000036748"
FT   TRANSMEM        480..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   LIPID           479
FT                   /note="O-palmitoyl serine; by host"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        194
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        351
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        381
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        423
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        504
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   509 AA;  58410 MW;  7F7ED9ED760DB2A6 CRC64;
     MVRTAVLILL LVRFSEPAEH CNAQMNSGPW RIKNLSIAPP KETLQKDVEI EIVETNMDEN
     VIIGYKGYYQ AYAYNGGSLD PNTRIEETME TLNVAKEDLL MWSIRRQCEV GEELIDQWGS
     DSDNCFRNKD GRGVWVFGKE LVKRQNNNHF ARHTCNRSWR CGVSTAKMYT RLECDNDNDE
     CKVTILDING ASINVTENTV LHRDGVSMVL KQKSTFSRRP EKVACLLIKD DKSDPRSVTR
     EHCLVDNDIF DLSKNTWLCK FNRCIKRKSE NVVKQRPPTW RHDVSAKHDE GASATKGDLM
     HIQEELMYEN DLLRMNLELM HAHINKLNNM LHNLIVSVAK VDERLIGNLM NNSVSSTFLS
     DDTFLLMPCT HPPPHTSNCY NNSIYKEGRW VANTDSSQCI DFNNYKELAI DDDIEFWIPT
     IGNTTYHENW KDASGWSFIA QQKSNLISTM ENTKFGGHTT SLSDITDMAK GELNAKLWSF
     MLGHAFSFML TVGVIIFLFC MVRNRSRAY