FUS_NPVGM
ID FUS_NPVGM Reviewed; 337 AA.
AC P04872;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 2.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Major envelope glycoprotein;
DE AltName: Full=gp67;
DE Flags: Fragment;
GN Name=GP67; Synonyms=P67;
OS Galleria mellonella nuclear polyhedrosis virus (GmNPV).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX NCBI_TaxID=307468;
OH NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6365591; DOI=10.1016/0014-5793(84)80137-4;
RA Blinov V.M., Gutorov V.V., Holodilov N.G., Iljichev A.A., Karginov V.A.,
RA Mikrjukov N.N., Mordvinov V.A., Nikonov I.V., Petrov N.A., Urmanov I.H.,
RA Vasilenko S.K.;
RT "Nucleotide sequence of the Galleria mellonella nuclear polyhedrosis virus
RT origin of DNA replication.";
RL FEBS Lett. 167:254-258(1984).
CC -!- FUNCTION: Envelope phosphoglycoprotein which mediates the fusion of
CC viral and host endosomal membranes leading to virus entry into the host
CC cell. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC membrane protein {ECO:0000305}. Host cell membrane {ECO:0000305};
CC Single-pass membrane protein {ECO:0000305}.
CC -!- PTM: Palmitoylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the baculoviridae gp64 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA25117.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X00410; CAA25117.1; ALT_FRAME; Genomic_DNA.
DR PIR; S07237; S07237.
DR SMR; P04872; -.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR GO; GO:0019048; P:modulation by virus of host process; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR InterPro; IPR004955; Baculovirus_Gp64.
DR Pfam; PF03273; Baculo_gp64; 1.
PE 3: Inferred from homology;
KW Fusion of virus membrane with host endosomal membrane;
KW Fusion of virus membrane with host membrane; Glycoprotein;
KW Host cell membrane; Host membrane; Lipoprotein; Membrane; Palmitate;
KW Phosphoprotein; Transmembrane; Viral envelope protein;
KW Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT CHAIN <1..>337
FT /note="Major envelope glycoprotein"
FT /id="PRO_0000132915"
FT CARBOHYD 76
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 271
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 301
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT NON_TER 337
SQ SEQUENCE 337 AA; 39000 MW; 2512B667BFABD8F1 CRC64;
SNTRVEETMK TLNVGKEDLL MWSIRQQCEV GEELIDRWGS DSDDCFRDNE GRGQWVKGKE
LVKRQNNNHF AHHTCNKSWR CGISTSKMYS KLECQDDTDE CQVYILDAEG NPINVTVDTV
LHRDGVSMIL KQKSTFTTRQ IKAACLLIKD DKNNPESVTR EHCLIDNDIY DLSKNTWNCK
FNRCIKRKVE HRVKKRPPTW RHNVRAKYTE GDTATKGDLM HIQEELMYEN DLLKMNIELM
HAHINKLNNM LHDLIVSVAK VDERLIGNLM NNSVSSTFLS DDTFLLMPCT NPPAHTSNCY
NNSIYKEGRW VANTDSSQCI DFSNYKELAI DDDVEIL
